Abstract

The overall goal of this project is to understand the molecular basis of eye growth during infancy using a monkey model. In particular, we are interested in the effect of aphakia on ocular growth and the factors that mediate these changes. Understanding the mechanism whereby aphakia alters ocular growth is important for the following reasons. First, it should make it possible to more accurately select the most appropriate intraocular lens power to implant into infantile eyes after cataract surgery. In addition by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth that occurs on certain pathological conditions such as retinopathy of prematurity. FUNDING NIH EY08544 $149,368 9/30/93 - 1/31/99 PUBLICATIONS Lambert, S.R. The effect of age on the retardation of axial elongation following a lensectomy in infant monkeys. Arch. Ophthalmol. 116:781-784, 1998. Lambert S.R. Ocular growth in early childhood Implications for pediatric cataract surgery. Operative Techniques in Cataract and Refractive Surgery 1:159-164, 1998. P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000165-39
Application #
6288147
Study Section
Project Start
1999-05-01
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Claw, Katrina G; George, Renee D; MacCoss, Michael J et al. (2018) Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems. BMC Genomics 19:488
Adekambi, Toidi; Ibegbu, Chris C; Cagle, Stephanie et al. (2018) High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis. Front Immunol 9:1481
Beck, Goichi; Maehara, Shunsuke; Chang, Phat Ly et al. (2018) A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. Mov Disord 33:805-814
Georgieva, Maria; Sia, Jonathan Kevin; Bizzell, Erica et al. (2018) Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun 86:
Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97
Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:
Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319
Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105
Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198
Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952

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