Abstract

Initiation of an antigen specific immune response classically requires activation of T cells via the TCR/CD3 complex and delivery of a second signal e.g. via CD28 of CD40L on T cells. It has been recognized that constant costimulation via CD3 and either CD28 or CD40L results in exponential expansion of T cells in vitro with massive production of TH1 cytokines and CC chemokines. The latter appears to mediate rapid internalization of CCR5, a major co-receptor for HIV and SIV which renders expanded CD4+ T cells refractory to HIV/SIV infection.
The aim of this project is to evaluate the capacity of CD3/CD28 expanded T cells collected prior to SIV infection but post influenza/tetanus toxoid immunization to reconstitute immune functions impaired by SIV infection in vivo. FUNDING AMFAR $116,653 1/01/98 - 3/31/99 Naval Medical Research Institute PUBLICATIONS Brice, G.T., Riley, J.L., Villinger, F., Mayne, A., Hillyer, C.D., June, C.H. and Ansari, A.A. Development of an animal for autotransfusion therapy In vitro characterization and analysis of anti-CD3/CD28 expanded cells. AIDS Res Hum Retrovirus 19:210-220, 1998. P51RR00165-38 1/1/1998 - 12/31/1998 Yerkes Regional Primate Research Center

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000165-40
Application #
6311864
Study Section
Project Start
1976-06-01
Project End
2001-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
40
Fiscal Year
2000
Total Cost
$84,458
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Claw, Katrina G; George, Renee D; MacCoss, Michael J et al. (2018) Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems. BMC Genomics 19:488
Adekambi, Toidi; Ibegbu, Chris C; Cagle, Stephanie et al. (2018) High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis. Front Immunol 9:1481
Beck, Goichi; Maehara, Shunsuke; Chang, Phat Ly et al. (2018) A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. Mov Disord 33:805-814
Georgieva, Maria; Sia, Jonathan Kevin; Bizzell, Erica et al. (2018) Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun 86:
Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97
Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:
Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319
Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105
Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198
Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952

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