This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The aim of this renewal AIDS-FIRCA application is to further characterize the process of incorporation of the SIV envelope (Env) glycoprotein into budding particles, the step in SIV morphogenesis that confers infectivity to virions. In this regard, our mutagenesis studies have led to the identification of domains within the carboxy-terminal third of the SIV transmembrane (TM) cytoplasmic tail that are necessary for the incorporation of the SIV Env into particles and virus infectivity. Of note, some of these domains are partially conserved in the cytoplasmic tail of the HIV-1 Env glycoprotein. Due to the relatedness of SIV and HIV-1, a better understanding of the mechanism that underlies Env incorporation into budding particles may provide useful information for the rational design of alternative anti-retroviral strategies.
Showing the most recent 10 out of 912 publications
