This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Cognitive neuroscientists have recently turned their attention to the resting state in humans, arguing for the existence of a default neural network that is tonically active at rest. Among the brain areas implicated in this resting state network, the dorsomedial prefrontal cortex is hypothesized to relate to reflecting on the mental states of self and others. Given the complexity of their social lives, as well as their potential capacity for self-awareness, it is possible that great apes also default to a resting state mode that involves thinking about mental states. If so, they should exhibit a similar pattern of resting brain metabolism as seen in human subjects. Here, we use 18F-FDG Positron Emission Tomography (PET) imaging to compare regional cerebral glucose metabolism at rest in monkeys, apes and humans. We collected scans from eight human, five chimpanzee and four macaque subjects. Macaques were scanned with a high resolution, small animal dedicated Concorde microPET scanner (~2 mm FWHM), chimpanzees were scanned with a Siemens HRRT (High Resolution Research Tomograph, ~2mm FWHM)), and humans were scanned with an ECAT EXACT 921 scanner (~5 mm FWHM). The 5% and 1% most metabolically active voxels were identified and compared across species. These analyses revealed common regions of activation across species, as well as species differences in activation that are plausibly related to differences in resting cognition. All three species showed dorsolateral prefrontal cortex (BA 46) activation, only humans and chimpanzees showed activation in medial prefrontal regions related to social cognition, and only humans showed activation in Wernicke's and Broca's areas that might reflect an inner mental monologue at rest.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
Schools of Medicine
United States
Zip Code
Maddox, S A; Kilaru, V; Shin, J et al. (2018) Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry 23:658-665
Li, Chun-Xia; Kempf, Doty J; Tong, Frank C et al. (2018) Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures. Comp Med :
Lacreuse, Agnès; Parr, Lisa; Chennareddi, Lakshmi et al. (2018) Age-related decline in cognitive flexibility in female chimpanzees. Neurobiol Aging 72:83-88
Meng, Yuguang; Hu, Xiaoping; Zhang, Xiaodong et al. (2018) Diffusion tensor imaging reveals microstructural alterations in corpus callosum and associated transcallosal fiber tracts in adult macaques with neonatal hippocampal lesions. Hippocampus 28:838-845
Mylvaganam, Geetha H; Chea, Lynette S; Tharp, Gregory K et al. (2018) Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV. JCI Insight 3:
Kamara, Dennis M; Gangishetti, Umesh; Gearing, Marla et al. (2018) Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease. J Alzheimers Dis 62:1815-1826
Ploquin, Mickaël J; Casrouge, Armanda; Madec, Yoann et al. (2018) Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage. J Int AIDS Soc 21:e25144
Fonseca, Jairo A; McCaffery, Jessica N; Caceres, Juan et al. (2018) Inclusion of the murine IgG? signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine. Vaccine 36:2799-2808
Tedesco, Dana; Thapa, Manoj; Chin, Chui Yoke et al. (2018) Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic ?? T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology 154:2178-2193
Robinson, Amy A; Abraham, Carmela R; Rosene, Douglas L (2018) Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. Geroscience 40:31-47

Showing the most recent 10 out of 912 publications