This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.While there is a significant positive correlation between the amounts of time a person engages in nearwork tasks (e.g. reading) and the incidence of myopia, there is no direct evidence of a causal association, and the nature of this relationship has remained a mystery for over a century (ethical considerations preclude the use of human subjects to address this question directly through empirical research). Our study determines whether prolonged performance of nearwork tasks could lead to the development of myopia. During the reporting period, we worked to identify an appropriate task and behavioral setup and to ensure that optical performance was appropriate. In daily sessions monkeys worked for food reinforcement on a visual discrimination task displayed on a computer located within arm's reach (at near). Over time, all subjects have undergone a myopic shift in refractive error, exhibiting zero or nearly zero refractive error. This monkey model will allow us to determine what aspects of the visual task contribute to the effects of refractive development and the development of myopia and will prove useful in clinical efforts to prevent myopia or reduce its progression.
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