This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project seeks to (1) Perform a cross-sectional analysis of HIV adaptation to HLA-class I restricted immune responses at a population and individual level to determine if HIV-1 polymorphisms associated with HLA alleles cluster within known HLA class I specific CD8+ CTL epitopes and if we can identify novel epitopes that are specific to African HLA alleles, (2) In 150 couples where we have documented recent transmission, determine the kinetics of CTL epitope reversion and escape as the virus adapts to moving from the HLA class I environment of the donor to that of the recipient. (3) In approximately 40 high-risk non-transmitting couples determine if the long-term non-transmitting partners display a bias in escape signatures that may contribute to lack of transmission.
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