This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiac disease due to myocardial fibrosis has been documented as the most common cause of death in captive chimpanzee populations. Myocardial fibrosis can result in heart failure or sudden cardiac death. EKGs, blood pressure monitoring, and echocardiography have been used to screen for cardiac disease, but are not always the best tools to detect fibrosis. In humans serum biomarkers are used to identify cardiac disease. Several of these biomarkers are being evaluated as a potential tool to predict heart disease I chimpanzees. However, the biomarkers appear to be species specific and related to the type of pathology causing heart disease. Cardiac troponin, BNP and several other biomarkers are being evaluated by a collaborative group led by Michael Lammey and John Ely at the Alamogordo Primate Facility. This project is a collaborative effort between Charles River and Yerkes to help characterize the cardiac biomarker profile in chimpanzees. Within the last year approximately 10 chimps have had serum collected for biomarker analysis in conjunction with EKG and echocardiography. The biomarker samples have been shipped to UC Davis for analysis, and the data will be correlated with cardiac examination results. The collection of biomarker samples has been completed but the echocardiograms will continue. The echocardiograms are going to be standardized based on results from The Great Ape Cardiac Disease project. Echocardiograms will then be recorded in a standardized format to be able to compare results with other institutions.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
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Special Emphasis Panel (ZRR1-CM-5 (01))
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Emory University
Schools of Medicine
United States
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Mascaro, Jennifer S; Rentscher, Kelly E; Hackett, Patrick D et al. (2018) Preliminary evidence that androgen signaling is correlated with men's everyday language. Am J Hum Biol 30:e23136
Forger, Nancy G; Ruszkowski, Elara; Jacobs, Andrew et al. (2018) Effects of sex and prenatal androgen manipulations on Onuf's nucleus of rhesus macaques. Horm Behav 100:39-46
Claw, Katrina G; George, Renee D; MacCoss, Michael J et al. (2018) Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems. BMC Genomics 19:488
Adekambi, Toidi; Ibegbu, Chris C; Cagle, Stephanie et al. (2018) High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis. Front Immunol 9:1481
Beck, Goichi; Maehara, Shunsuke; Chang, Phat Ly et al. (2018) A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. Mov Disord 33:805-814
Georgieva, Maria; Sia, Jonathan Kevin; Bizzell, Erica et al. (2018) Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun 86:
Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97
Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:
Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319
Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105

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