Kaposi's sarcoma is a neoplastic disease associated with AIDS, and retroperitoneal fibromatosis is a disease of macaques that is related to Kaposi's sarcoma. In this project we investigated infections of rhesus and cynomolgus macaques with retroperitoneal fibromatosis-associated herpesvirus (RFHV). Animals infected with RFHV showed signs of lymphoproliferative disease and developed an unusual proliferative arteriopathy. Transfer of RFHV into cynomolgus macaques resulted in a rapidly fatal myeloproliferative disorder characterized by circulating multinucleated giant cells. We also attempted to infect pigtailed macaques with Kaposi's sarcoma-associated herpesvirus, but were unable to demonstrate productive infection in these animals.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-37
Application #
6277555
Study Section
Project Start
1998-05-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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