To determine whether cholera toxin can induce mucosal immunity in macaques, we inoculated two pigtailed macaques intrarectally. When we tested various bodily fluids for antibodies to cholera toxin following inoculation, we found high titers in blood and lower titers in rectal and vaginal washes. The response was stronger in one monkey than in the other. We believe that improved sampling techniques will provide a better picture of the induced immune response.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-37
Application #
6277584
Study Section
Project Start
1998-05-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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