This project is divided into two groups. Both groups were inoculated with HIV-2/KR, a non-pathogenic molecular clone group 1 on 6/14/94 and group 2 on 8/30/94. Group 1 was challenged twice with HIV-2/287, a highly pathogenic isolate derived from in vivo passage in Macaca nemestrina. The first challenge dose, 10 TCID (8/18/95), produced only limited infection. The second challenge dose, 1000 TCID (6/17/96), infected the nave macaques, but produced little to no infection in the macaques previously exposed. The single exception, macaque L93210, was depleted of CD4+ cells by 10 weeks post-inoculation. One macaque died of acute gastric dilatation; one was euthanatized due to deterioration in a femoral joint that compromised use of the leg. Neither death appeared related to the experimental interventions. The second group of macaques was challenged with 100 TCID (10/8/96). Although all the macaques were infected, three of the seven macaques previously exposed to the KR clone did not develop depletion of the CD4+ cells up to 64 weeks post-challenge. This project is now closed and the macaques will be necropsied for histological examination.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-38
Application #
6116342
Study Section
Project Start
1999-05-01
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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