Low peak bone mass is a risk factor for the development of postmenopausal osteoporosis in women. Conceivably, the increased calcium demands of pregnancy and lactation could adversely affect peak bone mass. Studies of changes in bone mass during human pregnancy and lactation have shown no permanent deleterious effect, but most of the subjects have been mature women. Thus, the question remains whether or not bone mineral would recover if the demands of reproduction were imposed during adolescence when deposition of bone is accelerated. As the opportunity to study reproductive teenagers is severely restricted, we used macaques as a model. We followed through first pregnancy and lactation 125 young female macaques and 13 nonreproductive controls to examine the effects of early reproduction on bone mass. The average age was 4.0 years (human equivalent age = 12 years); the animals were sexually mature but had not yet completed growth. Using several methods (DEXA, histolog y an d biochemical assays), we identied and measured the bone lost and gained during reproduction. The animals gained total bone mineral during pregnancy, but during the first 3 months of lactation they lost somewhat over 3%, similar to bone loss reported for lactating women. The bone loss occurred in both compact and cancellous bone, including that of the vertebrae, which is a prime site for osteoporosis in postmenopausal women. However, the bone lost during reproduction had been restored by 3 months after weaning (6 months postpartum). Thus, the females slowed their rates of growth during reproduction, but experienced """"""""catch-up"""""""" growth after weaning. We were therefore unable to document any permanent loss of bone mineral in the adolescent reproductive macaque. The possible effects of multiple, closely spaced reproductive events at young ages were not studied. FUNDING NIH grants RR00166 and AR40813.
| Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11 |
| Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4 |
| Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257 |
| Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365 |
| Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116 |
| Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540 |
| Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867 |
| Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466 |
| Balakrishnan, Ashwini; Goodpaster, Tracy; Randolph-Habecker, Julie et al. (2017) Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues. Clin Cancer Res 23:3061-3071 |
| Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2017) Asymmetric Dichoptic Masking in Visual Cortex of Amblyopic Macaque Monkeys. J Neurosci 37:8734-8741 |
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