We have had a long-standing interest in membrane phosphoglycerides that contain esterified fatty acids with 4 to 6 cis double bonds. These fatty acids are members of families of polyunsaturated fatty acids that cannot be formed de novo by primates or other vertebrates, and must be provided in the diet if these animals are to reproduce, develop, grow, and maintain their health. The fatty acids also are of interest because they are subject to artifactual oxidation and to special mechanisms to prevent this oxidation and repair its effects, and there is reason to believe that disorders of these mechanisms occur in aged individuals, in atherosclerosis, and in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. We have been exploring the possibility that phosphoglycerides that contain polyunsaturated fatty acids with four or more cis double bonds may normally have an important structural effect on the nerve plasm a membrane lipid bilayer. We are in the process of completing detailed molecular modeling studies to identify factors that might influence the ability of the phosphoglycerides to interact with each other in simulated monolayers. We have almost completed an experimental study of the packing of these phosphoglycerides in monolayers. Experiments with unilamellar vesicles containing the phosphoglycerides are underway, and experiments with macaque brain prefrontal cortex synaptosome plasma membranes and synaptic vesicles (see above) are planned. FUNDING NIH grant RR00166 and the Howard Hughes Medical Institute.
| Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11 |
| Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4 |
| Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257 |
| Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365 |
| Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116 |
| Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540 |
| Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867 |
| Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466 |
| Balakrishnan, Ashwini; Goodpaster, Tracy; Randolph-Habecker, Julie et al. (2017) Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues. Clin Cancer Res 23:3061-3071 |
| Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2017) Asymmetric Dichoptic Masking in Visual Cortex of Amblyopic Macaque Monkeys. J Neurosci 37:8734-8741 |
Showing the most recent 10 out of 320 publications
