The primary goal of this research is to develop a macaque monkey model for complex-partial seizures during the first year of life. The research is important because an estimated 3-5% of children in the United States have at least one seizure before the age of three. There is concern that early seizures may adversely affect cognitive and emotional functioning during childhood. Cranial assemblies are implanted on project animals using stereotaxic surgical techniques. In previous years we attempted to induce seizures by the microinfusion of bicuculline methiodide into an area deep within the piriform cortex. Unfortunately this procedure was not reliable in obtaining seizures on a regular basis. Therefore, we tried two other protocols. First, in four animals we attempted to induce seizures by the infusion of drug into the hippocampus. Again, the results were inconsistent. Second, in another four animals, we induced seizures by infusing drug into the entorhinal cortex. The latter procedure was very successful, and we were able to obtain seizures in every animal on our first attempt. Follow-up studies indicated that a single prolonged seizure produced brain changes that were apparent on high-resolution MRI scans, and these changes were verified by histological examination. Our work over the past year has resulted in the first infant primate model of complex-partial seizures. FUNDING NIH grants RR00166 and MH01201. Gunderson, V.M., Gale, K.N., Dubach, M., Schwartzkroin, P.A., Born, D.E., and Wenzel, J. Seizures in young monkeys are associated with long-term behavioral deficits. Epilepsia 39 (Suppl. 6) 237, 1998. Born, D.E., Wenzel, H.J., Gunderson, V.M., Szot, P., Dubach, M.F., and Maravilla, K.R. Intrahippocampal bicuculline-induced seizures in young primates produce mesial temporal sclerosis. Epilepsia 39 (Suppl. 6) 134, 1998.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-39
Application #
6316743
Study Section
Project Start
1976-06-01
Project End
2002-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
2000
Total Cost
$105,178
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Balakrishnan, Ashwini; Goodpaster, Tracy; Randolph-Habecker, Julie et al. (2017) Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues. Clin Cancer Res 23:3061-3071
Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2017) Asymmetric Dichoptic Masking in Visual Cortex of Amblyopic Macaque Monkeys. J Neurosci 37:8734-8741

Showing the most recent 10 out of 320 publications