The specific aim of the proposed study is to evaluate the efficacy of a novel AIDS therapeutic, PPB2, when compared with the natural progression of disease in the pathogenic SHIV-229 macaque model system. Human immunodeficiency virus (HIV) infection and the progression to AIDS have challenged the scientific community for nearly two decades. Most of the anti-HIV drugs in use today reduce the level of free virus during treatment, but the number of virus-infected cells is not substantially affected. Therefore, virus-infected cells and the virus reservoir in infected tissues are major deficiencies of current therapy. The rapid appearance of HIV mutants with drug resistance is the other major challenge to clinical treatment of HIV infection. Because of these problems, there is an urgent need to continually investigate new therapeutics, particularly those with alternate mechanisms of action. This project will evaluate compounds that appear to exert their effects through i nteraction s with host cells, interfering with viral replication and/or establishing an effective anti-HIV immune response. We saw promising results with PPB2 in macaques chronically infected with our highly pathogenic SHIV-229. We are now expanding on these data and adding the complementary observations from a group of control (non-treated) animals. FUNDING NIH grant RR00166 and a contract with Hollis Eden Pharmaceuticals.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-40
Application #
6458044
Study Section
Project Start
2001-05-01
Project End
2002-04-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
McAdams, Ryan M; McPherson, Ronald J; Kapur, Raj P et al. (2017) Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates. Dev Neurosci 39:107-123

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