This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past year, Dr. Dorothy Mandell has successfully implemented a touch screen testing system to assess cognitive development with infants as young as 90-days old. We have also been working to expand the cognitive assessment battery in the computer environment to include measures that are sensitive to developmental changes in different levels of executive functioning, memory capacity, and spatial memory. Drs. Burbacher and Grant have continued to consult with a team of investigators from the Children's Hospital to develop new test procedures for use at the IPRL. Dr. Jim Phillips and Dr. Avery Weiss are providing the test equipment and expertise to study the longitudinal development of oculomotor function in infant primates. Dr. John Kelley is assisting with the design and implementation of test procedures to examine foveal development in young monkeys. Upgrades of our data collection and management programs have continued. We have successfully implemented the use of wireless technology in the lab and all data are now collected via DELL laptops or hand-held devices such as Palm Pilots. During 2005, a computerized visual acuity testing apparatus was developed with the expertise of Dr. Lynne Kiorpes and Dr. Ron Boothe, both experts in the field of psychophysics. Laboratory personnel are continuing to offer services to affiliate investigators in conjunction with the Reproductive Biology program. IPRL staff provides assistance with daily observations for menses, training animals for blood draws, ultrasound imaging and embryo transfers. Finally, the studies conducted in the laboratory since May, 2005 provided opportunities for training 14 undergraduate students. This program has been highly successful in meeting one of the major goals of the University, providing quality undergraduate training in research. In addition, one undergraduate honors student and on graduate student engaged in advanced research during the progress report period.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-45
Application #
7349349
Study Section
Special Emphasis Panel (ZRR1-CM-9 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
45
Fiscal Year
2006
Total Cost
$132,006
Indirect Cost
Name
University of Washington
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
McAdams, Ryan M; McPherson, Ronald J; Kapur, Raj P et al. (2017) Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates. Dev Neurosci 39:107-123

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