This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Color perception is one of the key features of our visual system that permits an appropriate interaction with our environment. Hence, the investigation of neuronal mechanisms forming the basis for color vision is one of the major goals in the field of retinal neuroscience. Processing of color signals starts already at the level of the retina, where the light responses of the different cone photoreceptor types are 'compared'and modulated. Among other mammalian species, humans and many of the non-human primates show one of the most highly developed systems for color vision. This system is based on three chromatically tuned cone types (red, green, and blue). Retinal ganglion cells receive and process the cones'signals and send them to higher visual centers of the brain. Up to date, research on color-coded ganglion cells of the primate retina focused on two distinct cell types: the midget ganglion cell (red-green processing) and the small bistratified ganglion cell (blue-yellow processing). However, further primate ganglion cell types have been discovered, which showed color-opponent responses to chromatic light stimuli. Though a detailed analysis is still missing, one can expect that these cell types also play a fundamental role in primate color vision. These cell types include the large bistratified ganglion cell, which is supposed to show blue-yellow opponent responses, similar to what has been observed in the small bistratified cell.
The aim of this project is to provide a comprehensive study on the anatomical and physiological properties of the large bistratified ganglion cell in the primate retina. The main focus will be directed at the analysis of the neuronal pathways and the synaptic mechanisms, underlying the chromatically tuned responses of this cell type.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
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Special Emphasis Panel (ZRR1-CM-8 (02))
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University of Washington
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Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
McAdams, Ryan M; McPherson, Ronald J; Kapur, Raj P et al. (2017) Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates. Dev Neurosci 39:107-123

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