The Division of Comparative Pathology provides anatomic and clinical pathology services to the various Divisions of the Center, affiliated scientists, collaborative scientists and other scientific investigators from the New England area who utilize the resources of this Center The number of requisitions for these services can be categorized as follows a Number of post-mortem examinations performed 401 b Number of biopsy specimens processed and examined 277 c Number of complete blood counts (CBCs) 3950 d Number of other clinical pathology requisitions including fecal examinations, chemistry analyses, urinalyses, cytological examinations, and fluid analyses 915 e Number of specimens collected for outside investigators 151 Complete postmortem and histopathologic examinations were performed on all nonhuman primates that died at the Center including abortuses and stillbirths from the several breeding colonies, animals dying of spontaneous disease while not involved in a research project, and those animals that died or were sacrificed while on specific studies The data generated from examination of those tissues is used to monitor outbreaks of infectious diseases in our colony, to provide ancillary support for ongoing research studies, and to provide diagnostic support to our clinical veterinary staff Finally, the diagnostic laboratory is fundamental in the recognition of certain natural diseases of captive nonhuman primates that may be explored as models of certain human diseases states Examples of these recognized and characterized previously at the Center include simian AIDS, colitis and colonic carcinoma, and glomerulonephritis Very active and large studies on the pathogenesis of AIDS are ongoing at the present time within the Division of Comparative Pathology, resulting from these initial observations and descriptions Further characterization of more recently described conditions of nonhuman primates are under investigation, including arteriopathy in SIV-infected Macaca mulatta, adenovirus infection in infant SIV-infected Macaca mulatta, and Pneumocystis carinii infection in SIV-infected macaques Publications Chalifoux LV, MacKey J, Carville A, Shvetz D, Lin KC, Lackner A, Mansfield KG Ultrastructural morphology of Enterocytozoon bieneusi in biliary epithelium of rhesus macaques (Macaca mulatta) Vet Pathol 35:292-296, 1998

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000168-40
Application #
6453778
Study Section
Project Start
2001-05-01
Project End
2002-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
40
Fiscal Year
2001
Total Cost
$111,112
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Shang, L; Smith, A J; Reilly, C S et al. (2018) Vaccine-modified NF-kB and GR signaling in cervicovaginal epithelium correlates with protection. Mucosal Immunol 11:512-522
Sonntag, Kai-Christian; Woo, Tsung-Ung W (2018) Laser microdissection and gene expression profiling in the human postmortem brain. Handb Clin Neurol 150:263-272
Almodovar, Sharilyn; Swanson, Jessica; Giavedoni, Luis D et al. (2018) Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol 31:206-222
Duke, Angela N; Meng, Zhiqiang; Platt, Donna M et al. (2018) Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys. J Pharmacol Exp Ther 366:145-157
Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105
Seth, Nitin; Simmons, Heather A; Masood, Farah et al. (2018) Model of Traumatic Spinal Cord Injury for Evaluating Pharmacologic Treatments in Cynomolgus Macaques (Macaca fasicularis). Comp Med 68:63-73
Mauney, Sarah A; Woo, Tsung-Ung W; Sonntag, Kai C (2018) Cell Type-Specific Laser Capture Microdissection for Gene Expression Profiling in the Human Brain. Methods Mol Biol 1723:203-221
Termini, James M; Church, Elizabeth S; Silver, Zachary A et al. (2017) Human Immunodeficiency Virus and Simian Immunodeficiency Virus Maintain High Levels of Infectivity in the Complete Absence of Mucin-Type O-Glycosylation. J Virol 91:
Ma, Qi; Ruan, Hongyu; Peng, Lisheng et al. (2017) Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. Proc Natl Acad Sci U S A 114:E8760-E8769
Shang, L; Duan, L; Perkey, K E et al. (2017) Epithelium-innate immune cell axis in mucosal responses to SIV. Mucosal Immunol 10:508-519

Showing the most recent 10 out of 365 publications