This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Division of Comparative Pathology provides anatomic and clinical pathology services to the various Divisions of the Center, affiliated scientists, collaborative scientists, and other scientific investigators from the USA who utilize the resources of this center. The diagnostic laboratory plays a critical role in the recognition of certain natural diseases of captive nonhuman primates that may be developed into animal models for various diseases of humans. Examples of nonhuman primate models for human diseases that have been developed at the Center include simian AIDS, colitis and colonic carcinoma, and glomerulonephritis. AIDS pathogenesis studies, using the SIV/rhesus macaque model, remain a major focus of the research conducted in the Division of Comparative Pathology. More recently described conditions of nonhuman primates that are currently being investigated for model development include SV40-induced oncogenesis, arteriopathy in SIV-infected rhesus, cryptosporidial infection in rhesus, and the pathogenesis of Mycobacterium avium infection in SIV-infected rhesus.
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