This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main objective of this project is to study the in vivo pathogenesis of different primary SIVsm lineages in rhesus macaques. Different strains of primary SIVsm lineages that have not undergone passage in rhesus macaques, display the viral diversity of different HIV-1 subtypes and may be significantly less virulent. Thus, infection of rhesus macaques with primary SIVsm isolates may better recapitulate the natural history of HIV infection, as compared to infection with pathogenic SIVmac239 infection. The SIV-specific immune response and its relation to the outcome of SIV infection in rhesus macaques infected with six different lineages of primary SIVsm isolates is being evaluated. These studies will provide insight into the viral and host determinants of disease progression to AIDS.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000168-48
Application #
7958385
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2009-05-01
Project End
2010-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
48
Fiscal Year
2009
Total Cost
$199,721
Indirect Cost
Name
Harvard University
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
Sonntag, Kai-Christian; Woo, Tsung-Ung W (2018) Laser microdissection and gene expression profiling in the human postmortem brain. Handb Clin Neurol 150:263-272
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