This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The goal of this proposal is to establish an animal model of long-term immunologic memory to measles vaccine in the rhesus monkey. Measles virus is pathogenic in rhesus monkeys and the immune responses of infected monkeys are similar to those in humans. Vaccination of monkeys with live-attenuated measles vaccine protects them from systemic infection and disease after challenge with pathogenic measles virus. There are two aims and hypotheses for this proposal. 1. Memory B and T cells circulate in the blood and through body tissues differently than do naive cells, and patterns of lymphocyte circulation and retention in tissues are related to the initial route of immunization. 2. The levels of memory B and T cells that persist during long-term memory are determined by the amount of viral antigen produced during the primary immune response.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000169-45
Application #
7349642
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
45
Fiscal Year
2006
Total Cost
$97,498
Indirect Cost
Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
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