This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Mesenchymal stem cells can be expanded and induced to terminally differentiate into a variety of cell types of mesenchymal origin thus providing the potential to replace or restore tissues damaged by disease. In addition, the use of mesenchymal stem cells with inserted genes may be the ideal treatment strategy for a variety of congenital and acquired illnesses, since this approach could provide a means for integration of healthy cells into host tissue with gene products that can restore or enhance organ function.
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