This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Objectives:1. To characterize conditions of exposure to a common indoor air pollutant (ETS) in monkeys during critical windows of development (ranging from early gestation to 13 months postnatal age) correlated to measures from ultrasonography, amniotic fluid and blood samples of the mother and/or infant.2. To determine the consequences in the lung of exposure to ETS in monkeys during critical perinatal periods of development (from early gestation to 13 months postnatal age) on immunological development of the Rhesus monkey.3. To determine if the same perinatal ETS exposure enhances neurotrophin production in the lungs in association with increased production of substance P in C-fibers resulting in exaggerated CNS respiratory responses.4. To determine if cessation of exposure to ETS after the perinatal period will ameliorate effects or be associated with persistent changes in the lung and its neural control.5. To determine the effects of ETS on NF-kappaB signaling to increase apopotosis in infant monkey lungs6. To evaluate the impact of perinatal exposure to ETS on brain development and cognitive function in the neonal Rhesus monkey.7. To examine the potential for interaction between tobacco smoke and alcohol on mitochondrial damage and atherogenesis.
Showing the most recent 10 out of 408 publications
