This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Objective: An essential part of wound healing is appropriate blood flow to an area of injury. Lack of appropriate blood flow leads to chronic inflammation and tissue destruction. This proposal tests the hypothesis that bacterial endotoxin stimulates new blood vessel generation as a part of wound healing, a process that is delayed with exposure to ozone, and is hyperinflammatory in the setting of impaired angiogenesis. Our three specific aims are 1) to establish the kinetics of angiogenesis using micro-PET based angiogenic imaging, 2) correlate angiogenic kinetics with markers of inflammation and apoptosis and 3) to determine the effect of ozone and inhibitors of angiogenesis on the duration of inflammation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000169-47
Application #
7715632
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2008-05-01
Project End
2009-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
47
Fiscal Year
2008
Total Cost
$27,111
Indirect Cost
Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
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