Abstract

The goal of this project is to determine the mechanism of nutritional programming of bile acid metabolism by breast-feeding vs. formula-feeding and the relationship to thyroid hormone levels.
The specific aims are to test the hypotheses that: 1) breast-feeding vs. formula-feeding differentially programs bile acid metabolism in adult baboons; and 2) nutritional programming of thyroxine (T4) and trilodothyronine (T3) concentrations mediates the programming of variables of bile acid formation. Results from our preliminary studies and from those of other groups of investigators have shown that breast-feeding vs. formula-feeding differentially programs lipoprotein concentrations, bile acid synthesis, and atherogenesis in baboons and humans. The proposed studies will identify the specific genes in bile acid metabolism that are programmed by early nutrition and the potential role of thyroid hormones. Expression of genes may be affected by multiple controls, including DNA methylation, transcription factors, or gene structure. The proposed studies will identify the specific genes in bile acid metabolism that are programmed by early nutrition and the potential role of thyroid hormones. Expression of genes may be affected by multiple controls, including DNA methylation, transcription factors, or gene structure. Identification of the genes affected by early diet in this study will provide a basis for future studies on the molecular mechanisms of nutritional programming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-02
Application #
6311878
Study Section
Project Start
1999-06-01
Project End
2004-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$38,551
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Mustonen, Allison; Gonzalez, Olga; Mendoza, Elda et al. (2018) Uremic encephalopathy in a rhesus macaque (Macaca mulatta): A case report and a brief review of the veterinary literature. J Med Primatol :
Koistinen, Keith; Mullaney, Lisa; Bell, Todd et al. (2018) Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings. Vet Pathol 55:905-915
Mahaney, Michael C; Karere, Genesio M; Rainwater, David L et al. (2018) Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance. J Med Primatol 47:3-17
Mangosing, Sara; Perminov, Ekaterina; Gonzalez, Olga et al. (2018) Uterine Tumors Resembling Ovarian Sex Cord Tumors in Four Baboons ( Papio spp.). Vet Pathol 55:753-758
Joganic, Jessica L; Willmore, Katherine E; Richtsmeier, Joan T et al. (2018) Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size. Am J Phys Anthropol 165:269-285
Shelton, Elaine L; Waleh, Nahid; Plosa, Erin J et al. (2018) Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. Pediatr Res 84:458-465
Perminov, Ekaterina; Mangosing, Sara; Confer, Alexandra et al. (2018) A case report of ovotesticular disorder of sex development (OT-DSD) in a baboon (Papio spp.) and a brief review of the non-human primate literature. J Med Primatol 47:192-197
Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Confer, Alexandra; Owston, Michael A; Kumar, Shyamesh et al. (2018) Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.). J Med Primatol 47:434-439
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290

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