This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preeclampsia is a disorder that occurs only during pregnancy and affects both the mother and the unborn baby. It affects at least 5 percent of all pregnancies and is a rapidly progressive condition characterized by high blood pressure, swelling and protein in the urine. Typically, preeclampsia occurs in the last 2nd or 3rd trimesters. Preeclampsia and other hypertensive disorders of pregnancy are a leading global cause of maternal and infant illness and death. By conservative estimates, these disorders are responsible for 76,000 deaths each year. This project will assess the safety of an antibody to digoxin in pregnant baboons by administering it four times daily over a period of 8 weeks during the third trimester of pregnancy.
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