This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. New antibiotics are constantly needed to treat infections with antibiotic resistant organisms. Cephalosporins need to be tested for bioavailability in chimpanzees, because there is a serum binding protein in humans and chimpanzees that limits availability. Thus, a pharmacokinetic study in chimpanzees predicts the level of antibiotic with which to initiate human trials. The proposed experiment will involve testing of 4 new cephalosporin compounds in 2 same-sex chimpanzees of similar weight. Compounds will be given IV every two weeks at a dose of 0.5 mg/kg. each dosing will involve the following blood sampling times; 0 or immediately prior to the dose, 15 min., 30 min., 1 hr., 2 hrs., 4 hrs., 8 hrs. and 24 hrs. Plasma samples will be tested for drug levels to determine the pharmacokinetics of these new drugs.
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