This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate objective of the proposed pilot study is to elucidate fundamental aspects of the genetic architecture of the baboon craniofacial complex in order to develop an appropriate animal model for study of the genetic contributions to normal variation in the human craniofacial complex. Understanding the nature of genetic influences on the regions of the cranium is of primary concern to a wide variety of clinicians. As it becomes increasingly possible to incorporate gene therapy and tissue engineering when approaching repair of craniofacial dysmorphology, studies that elucidate the genetic underpinnings of continuous phenotypes typifying normal variation in craniofacial morphology are of critical importance. The significance of this research will be the elucidation of the genetic architecture of the craniofacial complex in a species in phylogenetic proximity to humans. Examination of genetic contributions to normal variation in the baboon craniofacial complex will be addressed in two specific aims: 1) Collect quantitative measures of craniofacial morphology in baboons in order to characterize variation in biomedically-relevant phenotypes. 2) Explore fundamental aspects of the genetic architecture of craniofacial morphology in baboons. Fourteen craniometric points will be marked on lateral cephalographs of a sample of 400 baboons from the Southwest National Primate Research Center. Twenty linear and 5 angular metrics will be taken for each animal based on the craniometric points. A maximum likelihood variance decomposition method for pedigree data using the algorithm implemented in the software program SOLAR is the analytic platform for the analyses. Heritability of each trait will be estimated, and genetic and environmental correlations matrices will be examined for all traits. Additionally, preliminary linkage analysis will begin to look for Quantitative Trait Loci (QTL) harboring genes influencing variation in adult craniofacial morphology in baboons. This study of the genetic architecture of the craniofacial complex in baboons will provide the necessary ground work needed to establish the baboon as an animal model for the study of genetic and non-genetic influences on craniofacial variation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-08
Application #
7349877
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
8
Fiscal Year
2006
Total Cost
$11,603
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Shelton, Elaine L; Waleh, Nahid; Plosa, Erin J et al. (2018) Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. Pediatr Res 84:458-465
Perminov, Ekaterina; Mangosing, Sara; Confer, Alexandra et al. (2018) A case report of ovotesticular disorder of sex development (OT-DSD) in a baboon (Papio spp.) and a brief review of the non-human primate literature. J Med Primatol 47:192-197
Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Confer, Alexandra; Owston, Michael A; Kumar, Shyamesh et al. (2018) Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.). J Med Primatol 47:434-439
Mustonen, Allison; Gonzalez, Olga; Mendoza, Elda et al. (2018) Uremic encephalopathy in a rhesus macaque (Macaca mulatta): A case report and a brief review of the veterinary literature. J Med Primatol :
Koistinen, Keith; Mullaney, Lisa; Bell, Todd et al. (2018) Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings. Vet Pathol 55:905-915
Mahaney, Michael C; Karere, Genesio M; Rainwater, David L et al. (2018) Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance. J Med Primatol 47:3-17
Mangosing, Sara; Perminov, Ekaterina; Gonzalez, Olga et al. (2018) Uterine Tumors Resembling Ovarian Sex Cord Tumors in Four Baboons ( Papio spp.). Vet Pathol 55:753-758
Joganic, Jessica L; Willmore, Katherine E; Richtsmeier, Joan T et al. (2018) Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size. Am J Phys Anthropol 165:269-285
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290

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