This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The baboon model of bronchopulmonary dysplasia (BPD) developed over the last 19 years at SFBR is unique. Baboons develop a disease that is very similar, if not identical, to the human disease of BPD, but in a controlled environment. The purpose of the core facility remains the same: The NICU provides a model of lung disease in prematurebaboon infants and scientists and doctors across the US. are able to try new methods of curbing the lifelong effects of the disease. The ultimate goal is to prevent lung disease associated with prematurity.
The specific aims of the BPD Resource Core are 1) to produce and deliver by cesarean section 100 timed baboon pregnancies per year of known gestational ages, 2) to maintain these premature baboons in a neonatal intensive care unit for up to 28 days, 3) to provide tissue specimens taken at the time of delivery, during the animal's clinical course, and tailored to each investigator's needs, 4) to provide a Data management Core for animal information retrieval. During this funding period, the BPD Resource has brought together 9 established investigators with various backgrounds and expertise who are examining the roles of several hormones, selected growth factors, and other modulators on lung maturation. Each is funded by a NIH R01 grant. Eleven project titles listed below (from the 9 PIs and 2 studies overseen by Dr. Coalson).The focus in the first 5 years of the project was to develop better understanding of BPD in the baboon model; the emphasis during the current 5 years is to focus on chronic lung disease of infancy, which involves lack of alveolar formation and vascularization of the premature lung.Projects1. 'Ventilation model and CNS inlury in Baboons with BPD'  Dr. Terrie Inder2. 'Analysis of Airway Serpins in Baboon Models of BPD ' - Dr. Sule Cataltepe3. 'Closure of the primate ductus urteroisus' - Ronald Clyman, M.D.4. 'Treatment of BPD using Mimetics of Superoxide Dismutuse ' - Dr. James Crapo5. 'Regulation of Microvascular Development in BPD ' - Dr. William Maniscalco6. 'Molecular Targets in BPD' - Dr. Richard Pierce7. 'Hyaluronan and its Receptors in BPD '' - Dr. Savani8. 'Nitric Oxide in Lung Development and CLD ' - Dr. Phillip Shaul9. 'Neuropeptides, Immunity, and Lung Injury' - Dr. Mary Sunday10. 'Hypoxia-inducible factors in BPD ' - Dr. Carl White

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-09
Application #
7562401
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2007-05-01
Project End
2008-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
9
Fiscal Year
2007
Total Cost
$60,028
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
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Koistinen, Keith; Mullaney, Lisa; Bell, Todd et al. (2018) Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings. Vet Pathol 55:905-915
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Mangosing, Sara; Perminov, Ekaterina; Gonzalez, Olga et al. (2018) Uterine Tumors Resembling Ovarian Sex Cord Tumors in Four Baboons ( Papio spp.). Vet Pathol 55:753-758
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Shelton, Elaine L; Waleh, Nahid; Plosa, Erin J et al. (2018) Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. Pediatr Res 84:458-465
Perminov, Ekaterina; Mangosing, Sara; Confer, Alexandra et al. (2018) A case report of ovotesticular disorder of sex development (OT-DSD) in a baboon (Papio spp.) and a brief review of the non-human primate literature. J Med Primatol 47:192-197
Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Confer, Alexandra; Owston, Michael A; Kumar, Shyamesh et al. (2018) Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.). J Med Primatol 47:434-439
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290

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