This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Development and implementation of an effective HIV vaccine that would prevent infection is a logical approach to controlling the spread of the disease. Infection of rhesus macaques with the simian immunodeficiency virus (SIV) is the best animal model for HIV infection in humans. The goal of this project is to determine the immunogenicity of virus-like particles (VLPs) and enhanced immunogenicity of chimeric influenza hemagglutinin (HA) SHIV VLPs and CD40L/SHIV VLPs on the non-human primate model, we propose to study and compare the immunogenicity of SHIV VLPs, HASHIV VLPs and CD40L/SHIV VLPs in the rhesus macaques model to confirm the immunogenicity data obtained from the mouse model. We will immunize SHIV VLPs, HASHIV VLPs, and CD40L/SHIV VLPs intranasally at 0,1 , 2, 3,10,and 27 weeks. Blood, mucosal secretions (saliva, broncho-alveolar lavages and feces) will be collected at several time points pre- and post-vaccination (0, 5, IO, 12, 24, 27, 29, 32, 40 wks). Inguinal and axillary lymph nodes will be collected at 0, 12 and 40 weeks. ELISA antibody to SIV Gag and HIV Env, neutralizing antibody across different HIV strains, and CTL responses to SIV Gag and HIV Env will be tested and compared with different VLPs immunization. We expect that enhanced immune responses will be observed in chimeric HNSHIV VLP and CD40L/SHIV VLP immunized mice. Ultimately, information obtained from the monkey model will form a basis for the future development of a successful HIV vaccine in human trials.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-10
Application #
7716081
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2008-05-01
Project End
2009-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
10
Fiscal Year
2008
Total Cost
$7,993
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Shelton, Elaine L; Waleh, Nahid; Plosa, Erin J et al. (2018) Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. Pediatr Res 84:458-465
Perminov, Ekaterina; Mangosing, Sara; Confer, Alexandra et al. (2018) A case report of ovotesticular disorder of sex development (OT-DSD) in a baboon (Papio spp.) and a brief review of the non-human primate literature. J Med Primatol 47:192-197
Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Confer, Alexandra; Owston, Michael A; Kumar, Shyamesh et al. (2018) Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.). J Med Primatol 47:434-439
Mustonen, Allison; Gonzalez, Olga; Mendoza, Elda et al. (2018) Uremic encephalopathy in a rhesus macaque (Macaca mulatta): A case report and a brief review of the veterinary literature. J Med Primatol :
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Mangosing, Sara; Perminov, Ekaterina; Gonzalez, Olga et al. (2018) Uterine Tumors Resembling Ovarian Sex Cord Tumors in Four Baboons ( Papio spp.). Vet Pathol 55:753-758
Joganic, Jessica L; Willmore, Katherine E; Richtsmeier, Joan T et al. (2018) Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size. Am J Phys Anthropol 165:269-285
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290

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