This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Human immunodeficiency virus (HIV) was identified as the causative agent of AIDS more then 21 years ago and the virus has killed approximately 23 million people and is estimated to have infected nearly 46 million people worldwide. No effective vaccine is available for prevention of further spread of the virus. In this proposal, we will examine the immunogenicity of novel candidate AIDS vaccines in the baboon model to hopefully identify a suitable vaccine formulation for human trials. A total of 60 baboons are requested for the proposed project. Groups of 8 to 12 baboons will be used for testing the immunogenicity of different candidate vaccines. We plan to use 8 to 12 baboons for testing the immunogenicity of each candidate vaccine at 6 to 8 month intervals. Therefore, the total number of vaccine candidates tested will range from 5-7. The experimental objective for the entire proposal is to evaluate the relative immunogenicity of different vaccine candidates.
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