This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Excessive intra-abdominal (visceral) fat is associated with an increased risk of metabolic disease, including type 2 diabetes, dylipidemia, and hypertension. However, it is not known whether visceral fat is actually responsible for, or is simply associated with, these metabolic abnormalities. This proposal will evaluate the metabolic effects of decreasing intra-abdominal fat mass by resection of the omentum in overweight male baboons and will determine the mechanisms involved. It is expected that this procedure will result in improved muscle/adipose tissue and liver sensitivity to insulin (risk factors of type 2 diabetes), reduced levels of inflammation in the liver and muscle. Thus the information acquired will aid clinicians and researchers in focusing their efforts on reducing the societal burden of obesity-related metabolic disease.
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