This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastric emptying time and intestinal transit time are important factors in the assessment of normal gastrointestinal function. A reduced rate of gastric (stomach) emptying or 'gastroparisis'is a common finding in individuals with type 2 diabetes and patients with autoimmune disease. The purpose of this study will be to use the newly developed SmartPill (SmartPill Corporation, Buffalo, NY) technology to measure gastric emptying and intestinal transit time in the baboon model. Based on human studies, this new technology is capable of providing robust measures of these parameters in a non-invasive manner. The test subject must swallow a small indigestible capsule (26 x 13mm) that is slightly larger than a standard multivitamin pill. This capsule samples and then transmits data on pH, pressure, and temperature to a remove receiver as it passes through the intestine.
The aims of the study are as follows: 1. Quantify gastric emptying and small bowel transmit time following ingestion of a liquid meal in baboons using SmartPill technology. 2. Determine the repeatability of gastric emptying and small bowel transmit times for a liquid meal in baboons. After an overnight fast, animals will be lightly anesthetized with ketamine to facilitate placement of an orogastric tube into the stomach. The liquid meal bolus (Ensure, Abbott Labs) will be administered through the tube, quickly followed by administration of the SmartPill through the tube. Following liquid meal/SmartPill administration, animals will be radiographed than retuned to their individual cage and allowed to recover. Movement of the SmartPill capsule through the intestine will then be monitored by the SmartPill data receiver positioned outside the cage. Monitoring will last for up to 36 hours (or the time taken for the capsule to pass) after meal administration. The SmartPill capsule will be recoved following excretion. This procedure will be repeated in each animal to determine the test-to-test repeatability of this technique.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Texas Biomedical Research Institute
San Antonio
United States
Zip Code
Shelton, Elaine L; Waleh, Nahid; Plosa, Erin J et al. (2018) Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. Pediatr Res 84:458-465
Perminov, Ekaterina; Mangosing, Sara; Confer, Alexandra et al. (2018) A case report of ovotesticular disorder of sex development (OT-DSD) in a baboon (Papio spp.) and a brief review of the non-human primate literature. J Med Primatol 47:192-197
Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Confer, Alexandra; Owston, Michael A; Kumar, Shyamesh et al. (2018) Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.). J Med Primatol 47:434-439
Mustonen, Allison; Gonzalez, Olga; Mendoza, Elda et al. (2018) Uremic encephalopathy in a rhesus macaque (Macaca mulatta): A case report and a brief review of the veterinary literature. J Med Primatol :
Koistinen, Keith; Mullaney, Lisa; Bell, Todd et al. (2018) Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings. Vet Pathol 55:905-915
Mahaney, Michael C; Karere, Genesio M; Rainwater, David L et al. (2018) Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance. J Med Primatol 47:3-17
Mangosing, Sara; Perminov, Ekaterina; Gonzalez, Olga et al. (2018) Uterine Tumors Resembling Ovarian Sex Cord Tumors in Four Baboons ( Papio spp.). Vet Pathol 55:753-758
Joganic, Jessica L; Willmore, Katherine E; Richtsmeier, Joan T et al. (2018) Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size. Am J Phys Anthropol 165:269-285
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290

Showing the most recent 10 out of 444 publications