AdminCore The Administrative Core will provide leadership in research, research methodology development, and information dissemination on topics relevant to our overall TSRI- Alcohol Research Center (ARC) goal. The focus of our renewal is that dysregulation in the brain stress system mediates the transition from acute withdrawaltoprotractedabstinencetopromotevulnerabilitytorelapse,andourARCisdesignedtotranslate the discoveries of preclinical TSRI-ARC investigators for potential therapeutic use using proof-of-concept humanlaboratorytesting.ItcoordinatesallTSRI-ARCactivities,andwillhelpsupportandcoordinatetheTSRI- ARC with the Center at Large. Functions of the Administrative Core will be to provide scientific and administrative leadership for the by monitoring and enhancing collaborative interactions among the support Core and Research Components, to facilitate the dissemination of expertise between support Core and Research Components by organizing regular TSRI-ARC meetings, seminars, conferences and workshops to stimulate exchange of scientific information among the Center faculty and staff, to promote the sharing of multidisciplinary resources and services among the support Core components and investigators, and to disseminatenewresearchknowledgetoacademic,treatmentandlaycommunitiesbyengagingincommunity outreach activities designed to improve awareness, prevention and treatment of alcoholism and alcoholic diseases, and supporting regional and national research initiatives aimed at improving prevention and treatment of alcohol use disorders and addiction. It will arrange regular meetings of the Steering Committee andProgramAdvisoryCommitteeandmonthlymeetingsoftheParticipatingInvestigators.TheAdministrative CoreisorganizedtoensureproperfunctioningoftheCentertobenefitinvestigators,theirutilizationofCenter resources to enhance and expand alcohol research throughout the TSRI-ARC and Center at Large, and to providereviewandadvisoryfunctions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA006420-37
Application #
9836775
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
37
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Matzeu, Alessandra; Martin-Fardon, Rémi (2018) Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus. Front Neurol 9:720
Sidhu, Harpreet; Kreifeldt, Max; Contet, Candice (2018) Affective Disturbances During Withdrawal from Chronic Intermittent Ethanol Inhalation in C57BL/6J and DBA/2J Male Mice. Alcohol Clin Exp Res 42:1281-1290
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Blasio, Angelo; Wang, Jingyi; Wang, Dan et al. (2018) Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice. Biol Psychiatry 84:193-201
Kirson, Dean; Oleata, Christopher Shaun; Parsons, Loren Howell et al. (2018) CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats. Addict Biol 23:676-688
Matzeu, Alessandra; Kallupi, Marsida; George, Olivier et al. (2018) Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology 43:1010-1020

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