The Animal Production Core (A_PC) will continue to supply selectively bred and inbred P/NP (alcohol-preferring and -nonpreferring), HAD1/LAD 1, and HAD2/LAD2 (replicate high and low alcohol drinking) rats for research. These rats will be provided to researchers supported by or affiliated with our ARC (many are funded by R01 s and K awards, and their research is dependent on these selectively bred or inbred rats), and to collaborating/independent researchers at other Institutions (some also have active NIAAA grants that require our selectively bred and inbred rats).
The specific aims are: a) To continue to produce selectively bred P/NP rats for research use. b) To continue to produce HAD1/LAD1 and HAD2/LAD2 rats for research use, and c) To continue inbreeding ofP/NP, HAD1/LAD1 and HAD2/LAD2 rats. Additionally, although not budgeted, we would like to continue to assist in the creation of reciprocal congenic lines from inbred P/NP strains in order to narrow the critical region of Chr 4 QTL for alcohol preference, i.e., the QTL with a led score of 9.2, found in F2s from an iP x iNP (inbred P and NP) cross. Investigators will have a choice to use either selectively bred P/NP, HAD 1/LAD 1 and HAD2/LAD2 lines or their respective inbred strains. However, the APC would like to encourage efforts toward better phenotypic characterization of the iP and iNP strains, particularly strains iP5c and iP 10a because these inbred strains have been extensively genotyped and congenic lines are being raised. Additionally, genotypic and phenotypic characterizations of specific iliAD 1/iLAD 1 and iHAD2/iLAD2 strains will be encouraged. This is because inbred strains are isogenic constants (genotypically and phenotypically) and data collected from them are cumulative. Crosses can then be made from these inbred strains to synthesize various populations of desired specific characteristics (e.g., generation of F2 progeny and from them, conducting replicate short-term selective breeding for genetic correlative studies).

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA007611-16
Application #
6712896
Study Section
Project Start
2002-01-01
Project End
2007-11-30
Budget Start
2002-01-01
Budget End
2003-11-30
Support Year
16
Fiscal Year
2003
Total Cost
$372,111
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Weera, Marcus M; Agim, Zeynep S; Cannon, Jason R et al. (2018) Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines. Genes Brain Behav :e12515
Oberlin, Brandon G; Dzemidzic, Mario; Eiler 2nd, William J A et al. (2018) Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks. Psychopharmacology (Berl) 235:2725-2737
Chumin, Evgeny J; Goñi, Joaquín; Halcomb, Meredith E et al. (2018) Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder. Alcohol Clin Exp Res 42:889-896
Eiler 2nd, William J A; Dzemidzic, Mario; Soeurt, Christina M et al. (2018) Family history of alcoholism and the human brain response to oral sucrose. Neuroimage Clin 17:1036-1046
Weafer, Jessica; Ross, Thomas J; O'Connor, Sean et al. (2018) Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. Neuropsychopharmacology 43:2532-2538
Weera, Marcus M; Fields, Molly A; Tapp, Danielle N et al. (2018) Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference. Alcohol Clin Exp Res 42:432-443
Gerke, Steven P; Agley, Jon D; Wilson, Cynthia et al. (2018) An Initial Assessment of the Utility of Validated Alcohol and Drug Screening Tools in Predicting 30-Day Readmission to Adult General Medicine Wards. Am J Med Qual 33:397-404
Bujarski, Spencer; Jentsch, J David; Roche, Daniel J O et al. (2018) Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. Neuropsychopharmacology 43:1891-1899
Plawecki, Martin Henry; White, Kurt; Kosobud, Ann E K et al. (2018) Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers. Alcohol Clin Exp Res 42:1897-1908
Plawecki, Martin H; Windisch, Kyle A; Wetherill, Leah et al. (2018) Alcohol affects the P3 component of an adaptive stop signal task ERP. Alcohol 70:1-10

Showing the most recent 10 out of 308 publications