Alcohol use disorders (AUDs) are enormous public health problems, but there confinues to be a gap between scienfific knowledge about AUDs and the knowledge base of the health care and justice system workforces. Further, there has been erosion within the legal community of the understanding of the legal theory covering the status of animals in agriculture and in research. The increasing amount of electronic data related to AUDs is fragmented and not easily accessible to health care workers. Further, there are emerging issues within the legal community of the understanding of the legal theories covering biomedical research involving human and animal subjects. There is a crifical need to improve the understanding of alcoholism as a disease by health care providers and members of the judicial system, to improve the recognifion of AUDs through screening approaches, and to facilitate animal research supporting our understanding of AUDs. The objective and long term goal of the Translafional Research and Science Educafion component has been to advance alcoholism research to prevent alcohol-related problems and improve the treatment of alcohol-afflicted individuals. Our central hypotheses are threefold: 1) that by improving the educafion of health care providers regarding AUDs and providing them with real fime informaflon about their paflents'problems with alcohol use, we will improve care and decrease the harm related to alcohol abuse;2) that by educaflng members of the judicial system about research in AUDs, we will improve: (a) the handling of legal cases related to alcohol and (b) the court orders regarding the ability of researchers to carry out research requiring certificates of confidentiality;3) that dissemination of legal theory related to animals'status as property to law students and judges will counter the efforts of animal rights activists to block the use of animals in research.
The specific aims of this component will address each of these needs, extending established educafional programs and taking advantage of unique medical informaflcs competencies of the IU School of Medicine and Regenstrief Institute.

Public Health Relevance

Alcohol use disorders have a huge impact on health and society. The Translational Science and Education Component will address this through education of medical students, residents, social workers, and members of the legal professions and use of electronic health records to identify patients earlier in their course.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
United States
Zip Code
Weafer, Jessica; Ross, Thomas J; O'Connor, Sean et al. (2018) Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. Neuropsychopharmacology 43:2532-2538
Weera, Marcus M; Fields, Molly A; Tapp, Danielle N et al. (2018) Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference. Alcohol Clin Exp Res 42:432-443
Gerke, Steven P; Agley, Jon D; Wilson, Cynthia et al. (2018) An Initial Assessment of the Utility of Validated Alcohol and Drug Screening Tools in Predicting 30-Day Readmission to Adult General Medicine Wards. Am J Med Qual 33:397-404
Bujarski, Spencer; Jentsch, J David; Roche, Daniel J O et al. (2018) Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. Neuropsychopharmacology 43:1891-1899
Plawecki, Martin Henry; White, Kurt; Kosobud, Ann E K et al. (2018) Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers. Alcohol Clin Exp Res 42:1897-1908
Plawecki, Martin H; Windisch, Kyle A; Wetherill, Leah et al. (2018) Alcohol affects the P3 component of an adaptive stop signal task ERP. Alcohol 70:1-10
Houck, Christa A; Grahame, Nicholas J (2018) Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice. Psychopharmacology (Berl) 235:2167-2175
Kareken, David A (2018) Missing motoric manipulations: rethinking the imaging of the ventral striatum and dopamine in human reward. Brain Imaging Behav :
Czachowski, Cristine L; Froehlich, Janice C; DeLory, Michael (2018) The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats. Alcohol Clin Exp Res 42:453-460
Spence, John Paul; Reiter, Jill L; Qiu, Bin et al. (2018) Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4. Front Genet 9:513

Showing the most recent 10 out of 308 publications