The Pilot Project Component, which has been an integral part of the Indiana Alcohol Research Center (lARC) since its inception, will continue through years 26-30 (2012-2017).This component is a mechanism for funding promising, innovative research projects, for attracting new investigators to the alcohol research field, for developing methodologies that can be used by investigators in the lARC as well as investigators all over the worid, and for exploring areas of long-range relevance to the overall aims of the lARC. The flexibility inherent in the Pilot Project mechanishn has allowed the lARC to respond rapidly to unique scientific opportunities as they have arisen and to support research projects with good potential for evolving into extramurally funded research programs. Extramural funding for new innovative research proposals is often difficult to obtain if a proposal is not supported by preliminary results, and yet, preliminary results cannot be generated without funding. This is the classic dilemma faced by investigators who wish to move into new research areas and young investigators who are early in their careers. The pilot project mechanism alleviates this problem. During the past 24 years, the Pilot Project Component has had a demonstrable stimulatory effect on the growth of alcohol research on campus. It has served as a catalyst for the development of new research programs which, in turn, expand the training and research opportunities available to our students and fellows. The tangible evidence of the growth and success of this component includes the strong publication records of the pilot project investigators and the impressive rate of success of pilot project investigators in obtaining extramural research funding after having received lARC pilot project support. We have, and will continue to, monitor these outcomes 2-3 times a year in order to assess the effectiveness of the component. The administrative Core is responsible for managing the pilot projects, which are under the direction of Jan Froehlich with input from other members of the Steering Committee (David Crabb, David Kareken, Larry Lumeng, Sean O'Connor) and senior members of the Internal Board of Scientific Advisors (Howard Edenberg, Ting Kai Li, and Bill McBride).

Public Health Relevance

Development of preliminary data through pilot projects is essential for continued research advances. The pilot project component provides resources for exploration of new ideas and attracting new investigators to alcohol research.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAA1-GG)
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Indiana University-Purdue University at Indianapolis
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Houck, Christa A; Grahame, Nicholas J (2018) Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice. Psychopharmacology (Berl) 235:2167-2175
Kareken, David A (2018) Missing motoric manipulations: rethinking the imaging of the ventral striatum and dopamine in human reward. Brain Imaging Behav :
Czachowski, Cristine L; Froehlich, Janice C; DeLory, Michael (2018) The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats. Alcohol Clin Exp Res 42:453-460
Spence, John Paul; Reiter, Jill L; Qiu, Bin et al. (2018) Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4. Front Genet 9:513
McCane, Aqilah M; DeLory, Michael J; Timm, Maureen M et al. (2018) Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats. Alcohol 67:15-22
Vatsalya, Vatsalya; Stangl, Bethany L; Schmidt, Veronica Y et al. (2018) Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. Addict Biol 23:493-502
Sloan, M E; Klepp, T D; Gowin, J L et al. (2018) The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption. Neuropsychopharmacology 43:1530-1538
Nicholson, Emily R; Dilley, Julian E; Froehlich, Janice C (2018) Co-Administration of Low-Dose Naltrexone and Bupropion Reduces Alcohol Drinking in Alcohol-Preferring (P) Rats. Alcohol Clin Exp Res 42:571-577
Weera, Marcus M; Agim, Zeynep S; Cannon, Jason R et al. (2018) Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines. Genes Brain Behav :e12515
Oberlin, Brandon G; Dzemidzic, Mario; Eiler 2nd, William J A et al. (2018) Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks. Psychopharmacology (Berl) 235:2725-2737

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