Abstract

Human Alcohol Seeking Despite Aversion Prolonged alcohol use results in neuroadaptations leading to decreased sensitivity to alcohol, a shift from positive to negative reinforcement-based alcohol use, increased negative affect that drives further consumption, and, ultimately, aversion-resistant drinking. Aversion resistant drinking is a hallmark of more severe and treatment-resistant persistent alcohol use. It has been widely studied in animal models, but has not been well characterized in humans. This project aims to develop an objective measure of aversion resistant drinking in humans, modeled as alcohol self-administration despite aversion, and to characterize its underlying neural signatures. The positive impact of this project will be to advance the translation between preclinical models and clinical models, and to elucidate distinct mechanisms underlying alcohol use disorder progression in humans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA007611-31
Application #
9393543
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2017-12-15
Budget End
2018-11-30
Support Year
31
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Weera, Marcus M; Agim, Zeynep S; Cannon, Jason R et al. (2018) Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines. Genes Brain Behav :e12515
Oberlin, Brandon G; Dzemidzic, Mario; Eiler 2nd, William J A et al. (2018) Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks. Psychopharmacology (Berl) 235:2725-2737
Chumin, Evgeny J; Goñi, Joaquín; Halcomb, Meredith E et al. (2018) Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder. Alcohol Clin Exp Res 42:889-896
Eiler 2nd, William J A; Dzemidzic, Mario; Soeurt, Christina M et al. (2018) Family history of alcoholism and the human brain response to oral sucrose. Neuroimage Clin 17:1036-1046
Weafer, Jessica; Ross, Thomas J; O'Connor, Sean et al. (2018) Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. Neuropsychopharmacology 43:2532-2538
Weera, Marcus M; Fields, Molly A; Tapp, Danielle N et al. (2018) Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference. Alcohol Clin Exp Res 42:432-443
Gerke, Steven P; Agley, Jon D; Wilson, Cynthia et al. (2018) An Initial Assessment of the Utility of Validated Alcohol and Drug Screening Tools in Predicting 30-Day Readmission to Adult General Medicine Wards. Am J Med Qual 33:397-404
Bujarski, Spencer; Jentsch, J David; Roche, Daniel J O et al. (2018) Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. Neuropsychopharmacology 43:1891-1899
Plawecki, Martin Henry; White, Kurt; Kosobud, Ann E K et al. (2018) Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers. Alcohol Clin Exp Res 42:1897-1908
Plawecki, Martin H; Windisch, Kyle A; Wetherill, Leah et al. (2018) Alcohol affects the P3 component of an adaptive stop signal task ERP. Alcohol 70:1-10

Showing the most recent 10 out of 308 publications