CARC RC3: ALCOHOL USE DISORDER AND AGING IN HIV: THE ROLE OF THE MICROBIOTA & INFLAMM-AGING Excessive alcohol use contributes to the pathogenesis of a variety of geriatric medical conditions. Hypertension, heart failure, diabetes, chronic obstructive pulmonary disease, osteoporosis and cognitive impairment all occur at the intersection between Alcohol Use Disorder (AUD) and old age. Less appreciated is the connection between AUD and biological aging although some data suggests that harmful alcohol intake leads to precocious aging at the cellular level. Similarly, Human Immunodeficiency Virus (HIV) infection appears to accelerate the aging process. Chronologically young HIV+ persons are afflicted with many of the same geriatric aliments common to advanced age including the geriatric frailty syndrome and increases in senescent immune cells. Given these findings, an enhanced understanding of contributing factors and underlying mechanisms resulting in accelerated aging in HIV represents a critical public health concern. It is currently unknown whether or not AUD in HIV-infected patients hastens biological aging and what mechanisms may be involved. We propose a model of alcohol-induced aging by which HIV and AUD interact to accelerate the rate of aging through their overlapping effects on the gastrointestinal tract microbiota, which, in turn, perpetuates a chronic pro-inflammatory state. This Research Component proposes the overarching hypothesis that excessive alcohol use in HIV-infected individuals accelerates aging. We further hypothesize that alimentary tract dysbiosis in HIV-infected individuals with alcohol use disorder accelerates aging by amplifying inflamm-aging. These hypotheses will be tested through the conduct of a longitudinal cohort study of HIV+ patients in New Orleans. Three Objectives will be achieved during the course of this study: (1) To determine the effects of AUD on the alimentary tract microbiota in HIV- infected individuals. The hypothesis that AUD reduces microbial community diversity and alters taxonomic membership will be tested by phylogenetic analysis of ribosomal DNA sequences from oral and stool samples. (2) To resolve the roles of AUD & the microbiota in escalating inflamm-aging in HIV+ patients. This will test the hypothesis that harmful alcohol use results in immune activation and senescence through assays characterizing blood cell phenotypes and function. (3) To assess the influence of AUD, the microbiota & inflamm-aging on biological age in HIV. A multidimensional Profile of Aging will be used to test the hypothesis that AUD and/or the microbiota and/or inflamm-aging accelerate biological aging in people living with HIV / AIDS. The knowledge gained from this study has significant potential to identify novel therapeutic targets for the treatment of AUD-induced frailty and geriatric medical conditions in HIV seropositive patients.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAA1)
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Louisiana State Univ Hsc New Orleans
New Orleans
United States
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Theall, Katherine P; Felker-Kantor, Erica; Wallace, Maeve et al. (2018) Considering high alcohol and violence neighborhood context using daily diaries and GPS: A pilot study among people living with HIV. Drug Alcohol Depend 187:236-241
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2018) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses 34:178-184
Samuelson, Derrick R; Burnham, Ellen L; Maffei, Vincent J et al. (2018) The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol 314:L107-L117
Glick, Jennifer L; Theall, Katherine P; Andrinopoulos, Katherine M et al. (2018) The Role of Discrimination in Care Postponement Among Trans-Feminine Individuals in the U.S. National Transgender Discrimination Survey. LGBT Health 5:171-179
Molina, Patricia E; Nelson, Steve (2018) Binge Drinking's Effects on the Body. Alcohol Res 39:99-109
Molina, Patricia E; Simon, Liz; Amedee, Angela M et al. (2018) Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings. Alcohol Alcohol 53:439-447
Ford Jr, Stephen M; Simon Peter, Liz; Berner, Paul et al. (2018) Differential contribution of chronic binge alcohol and antiretroviral therapy to metabolic dysregulation in SIV-infected male macaques. Am J Physiol Endocrinol Metab :
Boule, Lisbeth A; Ju, Cynthia; Agudelo, Marisela et al. (2018) Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 66:35-43
Glick, Jennifer L; Andrinopoulos, Katherine M; Theall, Katherine P et al. (2018) ""Tiptoeing Around the System"": Alternative Healthcare Navigation Among Gender Minorities in New Orleans. Transgend Health 3:118-126
Glick, Jennifer L; Theall, Katherine; Andrinopoulos, Katherine et al. (2018) For data's sake: dilemmas in the measurement of gender minorities. Cult Health Sex :1-16

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