Scientific Resource Core The primary goal of the UNC Alcohol Research Center (ARC) is to increase understanding of the molecular and cellular pathogenesis in alcoholism. The purpose of the Scientific Resource Core (SRC) is to facilitate and extend this integrated research effort by providing access to cutting-edge technology, shared facilities, resources and technical expertise. In addition, the SRC fosters interaction among ARC investigators with the explicit purpose of increasing coordination and cohesiveness among individual research components. In this renewal application, the SRC has two specific goals. First, the SRC will support functional connectivity magnetic resonance imaging (fcMRI) studies designed to discover novel alcohol-induced changes in neural circuit connectivity, and activity, spanning multiple phases of addiction and mammalian species. This work will be conducted in an expert-driven environment within the SRC using shared facilities provided by the UNC Biomedical Research Imaging Center (BRIC). Access to cutting-edge imaging technologies and high end instrumentation in the BRIC significantly enhances the capabilities of Research Components by providing rigorous methods, sophisticated facilities, user support, and quality control of imaging. Second, the SRC provides facilities, resources, and expertise to allow measurement of alcohol-induced changes in gene and protein expression, and neural circuit function. These centralized facilities allow rigorous, standardized, and quality-controlled data collection across a variety of models, and extends the capability of Research Components to include novel methods. To assure effective functioning of the Core and to facilitate the integrative efforts of the ARC, the SRC holds a monthly meeting (chaired by Dr. Hodge) of ARC investigators that evaluates progress and provides a venue for data and idea sharing. Access to these resources, and integrative environment, is a highly significant feature of the ARC that contributes to the accomplishment of our shared goals. Together, these services and resources provide the Research Components with the unique capability of delineating alcohol-induced molecular changes in specific brain regions that are associated with altered neural circuit connectivity. This synergistic effort will provide novel insight into mechanisms of maladaptive changes in neural circuitry that underlie alcohol addiction. Moreover, this innovative and integrative strategy represents a clear advantage to conducting the proposed research as Center rather than separate research efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011605-23
Application #
9830538
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
23
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Jaramillo, Anel A; Randall, Patrick A; Stewart, Spencer et al. (2018) Functional role for cortical-striatal circuitry in modulating alcohol self-administration. Neuropharmacology 130:42-53
Vetreno, Ryan P; Lawrimore, Colleen J; Rowsey, Pamela J et al. (2018) Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin. Front Neurosci 12:200
Broadwater, Margaret A; Lee, Sung-Ho; Yu, Yang et al. (2018) Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood. Addict Biol 23:810-823
Fiorenza, Amanda M; Shnitko, Tatiana A; Sullivan, Kaitlin M et al. (2018) Ethanol Exposure History and Alcoholic Reward Differentially Alter Dopamine Release in the Nucleus Accumbens to a Reward-Predictive Cue. Alcohol Clin Exp Res 42:1051-1061
Hwa, Lara S; Neira, Sofia; Pina, Melanie M et al. (2018) Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling. Neuropsychopharmacology :
Faccidomo, Sara; Swaim, Katarina S; Saunders, Briana L et al. (2018) Mining the nucleus accumbens proteome for novel targets of alcohol self-administration in male C57BL/6J mice. Psychopharmacology (Berl) 235:1681-1696
Bohnsack, John Peyton; Hughes, Benjamin A; O'Buckley, Todd K et al. (2018) Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence. Neuropsychopharmacology 43:1518-1529
Coleman Jr, Leon G; Zou, Jian; Qin, Liya et al. (2018) HMGB1/IL-1? complexes regulate neuroimmune responses in alcoholism. Brain Behav Immun 72:61-77
Fish, E W; Wieczorek, L A; Rumple, A et al. (2018) The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice. Behav Brain Res 338:173-184
Beattie, Matthew C; Reguyal, Christopher S; Porcu, Patrizia et al. (2018) Neuroactive Steroid (3?,5?)3-hydroxypregnan-20-one (3?,5?-THP) and Pro-inflammatory Cytokine MCP-1 Levels in Hippocampus CA1 are Correlated with Voluntary Ethanol Consumption in Cynomolgus Monkey. Alcohol Clin Exp Res 42:12-20

Showing the most recent 10 out of 227 publications