The successful recruitment and retention of willing, eligible, racially diverse study subjects is an expensive, labor-intensive activity that is often duplicated by research teams unless a centralized resource is available. Moreover, it benefits from an infrastructure, which includes racially and linguistically diverse staff, culturally competent research teams, an informed public, and supportive, involved community based contacts. Over the past ten years, we have successfully developed this infrastructure and named it the Harvard Cooperative Program on Aging (HCPOA). It has gained community respect as an academic institution that is committed to the health of all older people. The HCPOA has also achieved a number of milestones, including the development of a Level of Intrusiveness Scale for assessing the level of intrusiveness of research study components and predicting the likelihood of recruitment success, defining research benefits, examining the cultural and linguistic requirements of research staff and making available supplemental translators. The proposed recruitment core will continue to support the recruitment and retention of subjects for intervention development studies, pilot projects, and other studies. We will work with the DIDP to provide pre-recruitment education and post-study information dissemination.
The specific aims of the RRCA are 1) To support clinically-based OAIC IDS and pilot projects by providing sources of well-characterized elderly subjects who meet each study's entry criteria; 2) To increase the recruitment of minority populations for clinical research projects; 3) To develop and validate a procedure for the allocation of recruitment resources for grant submissions; 4) To develop new research projects and training activities using the registry database; and 5) To disseminate information to registry participants, and members of the local lay and professional communities informing them of research projects results, foster health promotion and disease prevention practices, attract new members to the registry, and sustain the interest of existing members in future research participation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Comprehensive Center (P60)
Project #
2P60AG008812-11A1
Application #
6502851
Study Section
Project Start
1990-03-01
Project End
2006-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
11
Fiscal Year
2001
Total Cost
$230,705
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Foley, Jessica M; Salat, David H; Stricker, Nikki H et al. (2016) Glucose Dysregulation Interacts With APOE-?4 to Potentiate Temporoparietal Cortical Thinning. Am J Alzheimers Dis Other Demen 31:76-86
Stricker, Nikki H; Salat, David H; Kuhn, Taylor P et al. (2016) Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum. Am J Alzheimers Dis Other Demen 31:68-75
Fredman, Lisa; Gordon, Sheryl A; Heeren, Timothy et al. (2014) Positive affect is associated with fewer sleep problems in older caregivers but not noncaregivers. Gerontologist 54:559-69
Foley, Jessica M; Salat, David H; Stricker, Nikki H et al. (2014) Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults. Am J Alzheimers Dis Other Demen 29:222-35
Leritz, Elizabeth C; Shepel, Juli; Williams, Victoria J et al. (2014) Associations between T1 white matter lesion volume and regional white matter microstructure in aging. Hum Brain Mapp 35:1085-100
Williams, Victoria J; Leritz, Elizabeth C; Shepel, Juli et al. (2013) Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults. Hum Brain Mapp 34:1826-41
Morley, John E (2013) Systolic hypertension should not be treated in persons aged 80 and older until blood pressure is greater than 160 mmHg. J Am Geriatr Soc 61:1197-8
Jones, Richard N; Marsiske, Michael; Ball, Karlene et al. (2013) The ACTIVE cognitive training interventions and trajectories of performance among older adults. J Aging Health 25:186S-208S
Stricker, Nikki H; Salat, David H; Foley, Jessica M et al. (2013) Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning. J Int Neuropsychol Soc 19:925-37
Salat, David H; Williams, Victoria J; Leritz, Elizabeth C et al. (2012) Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults. Neuroimage 59:181-92

Showing the most recent 10 out of 118 publications