The overall goal of the Yale OAIC is to enhance the likelihood of successful aging as shown by the maintenance of physical, social, psychological, and cognitive function in elderly persons. Within the context of this goal, over the next five years the center will: 1) conduct IDSs to determine the efficacy of impairment-based interventions at preventing specific disabilities; 2) conduct studies to better understand the pathophysiology of disabling conditions by exploring the mechanisms of response to interventions; 3) develop and refine methods to conduct trials of promising interventions; 4) train young investigators capable of conducting studies of promising interventions; 5) facilitate collaboration among investigators withexpertise relevant to understanding disabilities; and 6) translate research findings into improved health care for older persons. The four IDSs proposed for the renewal include a trial of PREHABilitation strategies for at-risk elders, with Dr. Thomas Gill as PL; a driver-related rehabilitative intervention for the elderly, with Dr. Richard Marottoli as PL; use of attention training to enhance driving skills with Dr. Emily Richardson as PL; and a study of the mechanisms of insulin resistance in older persons, with Dr. Gerald Shulman as PL. A key aim of each IDS is to explore the mechanisms which underlie the effects of the intervention in order to determine the """"""""disabling process"""""""". This is established in the third study by determining the intermediary (mediating) response variables. In the fourth study, state-of-the-art nuclear magnetic resonance (NMR) and stable isotope technology will provide insights into the pathogenesis of insulin resistance in aging, and the mechanisms by which various interventions might influence this process.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Comprehensive Center (P60)
Project #
5P60AG010469-07
Application #
2748507
Study Section
Special Emphasis Panel (ZAG1-DAG-9 (M6))
Project Start
1992-09-30
Project End
2002-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kumashiro, Naoki; Yoshimura, Toru; Cantley, Jennifer L et al. (2013) Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology 57:1763-72
Tinetti, Mary E; Baker, Dorothy I; King, Mary et al. (2008) Effect of dissemination of evidence in reducing injuries from falls. N Engl J Med 359:252-61
Fortinsky, Richard H; Baker, Dorothy; Gottschalk, Margaret et al. (2008) Extent of implementation of evidence-based fall prevention practices for older patients in home health care. J Am Geriatr Soc 56:737-43
Marottoli, Richard A; Allore, Heather; Araujo, Katy L B et al. (2007) A randomized trial of a physical conditioning program to enhance the driving performance of older persons. J Gen Intern Med 22:590-7
Baker, Dorothy I; Gottschalk, Margaret; Bianco, Luann M (2007) Step by step: integrating evidence-based fall-risk management into senior centers. Gerontologist 47:548-54
Chou, William C; Tinetti, Mary E; King, Mary B et al. (2006) Perceptions of physicians on the barriers and facilitators to integrating fall risk evaluation and management into practice. J Gen Intern Med 21:117-22
Belcher, Vernee N; Fried, Terri R; Agostini, Joseph V et al. (2006) Views of older adults on patient participation in medication-related decision making. J Gen Intern Med 21:298-303
Levy, Becca R; Slade, Martin D; May, Jeanine et al. (2006) Physical recovery after acute myocardial infarction: positive age self-stereotypes as a resource. Int J Aging Hum Dev 62:285-301
Baker, Dorothy I; King, Mary B; Fortinsky, Richard H et al. (2005) Dissemination of an evidence-based multicomponent fall risk-assessment and -management strategy throughout a geographic area. J Am Geriatr Soc 53:675-80
Brown, Cynthia J; Gottschalk, Margaret; Van Ness, Peter H et al. (2005) Changes in physical therapy providers' use of fall prevention strategies following a multicomponent behavioral change intervention. Phys Ther 85:394-403

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