The Indiana University Multipurpose Arthritis Center (IUMPAC) consists of a Biomedical Research Component, an Education/Epidemiology/Health Services Research (EEHSR) Component and an Administration Unit. Major biomedical research interests include articular cartilage biology, pathogenesis of articular cartilage breakdown in osteoarthritis (OA), causes of pain and disability in OA, amyloidosis, immunologic tolerance, and pathogenesis of dermatomyositis. Six new Developmental/Feasibility studies are proposed in this application: they include projects related to gelatinase (type XI collagenase) activity in OA cartilage; the development of methodology for documenting the presence of muscular reflexes that protect joints; the effects of eicosanoids on release of neurotransmitters from peripheral and spinal cord neurons; the efficacy of ultrasound technology for reliable reproducible measurement of articular cartilage thickness and roughening; the effects of lymphocyte proteases on endothelial cell permeability; and anti-phospholipid antibodies. Our EEHSR Component is concerned with training of Fellows, house staff, medical students and arthritis health professionals (AHPs) and includes outreach programs and a variety of interactions with community organizations. Three new EEHSR projects are proposed: one examines lower extremity weakness as a risk factor for pain and disability in OA. The second examines muscle strength as an outcome variable in patients with hip fracture admitted to nursing homes, and the third examines clinical and economic effects of patient education in OA. To support the research activities of IUMPAC 4 Core Units are proposed: Protein Chemistry, Molecular Biology, Biostatistics and Data Acquisition. Overall Center activities are supported by an Administration Unit.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Indiana University-Purdue University at Indianapolis
Schools of Medicine
United States
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Mazzuca, Steven A; Brandt, Kenneth D; Katz, Barry P et al. (2007) Risk factors for early radiographic changes of tibiofemoral osteoarthritis. Ann Rheum Dis 66:394-9
Merle-Vincent, F; Vignon, E; Brandt, K et al. (2007) Superiority of the Lyon schuss view over the standing anteroposterior view for detecting joint space narrowing, especially in the lateral tibiofemoral compartment, in early knee osteoarthritis. Ann Rheum Dis 66:747-53
Otterness, Ivan G; Brandt, Kenneth D; Le Graverand, Marie-Pierre Hellio et al. (2007) Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing. Arthritis Rheum 56:3644-9
Mazzuca, S A; Brandt, K D; Eyre, D R et al. (2006) Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis. Ann Rheum Dis 65:1055-9
Brandt, Kenneth D; Mazzuca, Steven A (2006) Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. Rheum Dis Clin North Am 32:217-34, xi-xii
Mazzuca, S A; Brandt, K D; Katz, B P et al. (2006) Comparison of quantitative and semiquantitative indicators of joint space narrowing in subjects with knee osteoarthritis. Ann Rheum Dis 65:64-8
Mazzuca, Steven A; Poole, A Robin; Brandt, Kenneth D et al. (2006) Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis. J Rheumatol 33:1147-51
Mikesky, Alan E; Mazzuca, Steven A; Brandt, Kenneth D et al. (2006) Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum 55:690-9
Hellio Le Graverand, M-P; Brandt, K D; Mazzuca, S A et al. (2006) Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis. Osteoarthritis Cartilage 14:1189-95
Brandt, Kenneth D; Mazzuca, Steven A; Katz, Barry P et al. (2005) Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 52:2015-25

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