The long-term objectives of this proposal are: 1) to expand efforts directed towards the education of health professionals, patients, families, and the general public; 2) to develop, implement and evaluate proteotype community/health services programs at a high level of scientific endeavor; and 3) to expand clinical and basic research efforts. New programs in education include 1) an evaluation of use of the education-influential in teaching rheumatology to family practice training units; 2) studies of continuing graduate medical education in arthritis with emphasis upon involvement of the learner in the identification of objectives; and 3) augmentation of an audiovisual library as an umbrella educational resource. Specific new community programs include 1) a systems analysis of arthritis halth care delivery in Northeast Ohio; 2) identification of the legal needs of arthritis (chronically ill) patients; 3) studies of the perceived needs of arthritis patients, and available resources to meet those needs as viewed by the patient and community health nurses; 4) the establishment of an industrial data base pertaining to arthritis problems and management in Northeast Ohio; and 5) an evaluation of NEOMAC/community organizationsl behavioral interrelationships. Research programs are targeted to study cartilage metabolism and osteoarthritis, mediators of inflammation, acute phase reactants, the immune response in arthritis, genetic/clinical interplays in ankylosing spondylitis, and myopathic disorders. Core programs include a cell/tissue culture unit, and an evaluation/education core as an overall resource to Center project components. Administration includes administrative policy, executive, steering (operations), and community advisory committees to fully interdigitate Center/University/community interface.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020618-12
Application #
3108207
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1978-12-01
Project End
1992-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Miwa, Hazuki E; Gerken, Thomas A; Huynh, Tru D et al. (2009) Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5. Biochim Biophys Acta 1790:161-72
Atif, U; Philip, A; Aponte, J et al. (2008) Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. Osteoarthritis Cartilage 16:1174-7
Kraus, V B; Jordan, J M; Doherty, M et al. (2007) The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis Cartilage 15:120-7
Miwa, Hazuki E; Gerken, Thomas A; Huynh, Tru D et al. (2006) Mammalian expression of full-length bovine aggrecan and link protein: formation of recombinant proteoglycan aggregates and analysis of proteolytic cleavage by ADAMTS-4 and MMP-13. Biochim Biophys Acta 1760:472-86
Holderbaum, D; Malvitz, T; Ciesielski, C J et al. (2005) A newly described hereditary cartilage debonding syndrome. Arthritis Rheum 52:3300-4
Denko, Charles W; Malemud, Charles J (2005) Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases. Semin Arthritis Rheum 35:24-34
Ievers-Landis, Carolyn E; Burant, Christopher; Drotar, Dennis et al. (2005) A randomized controlled trial for the primary prevention of osteoporosis among preadolescent girl scouts: 1-year outcomes of a behavioral program. J Pediatr Psychol 30:155-65
Vashishth, D (2005) Collagen glycation and its role in fracture properties of bone. J Musculoskelet Neuronal Interact 5:316
Denko, Charles W; Malemud, Charles J (2005) Serum growth hormone and insulin but not insulin-like growth factor-1 levels are elevated in patients with fibromyalgia syndrome. Rheumatol Int 25:146-51
Denko, Charles W; Malemud, Charles J (2004) Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus. BMC Musculoskelet Disord 5:37

Showing the most recent 10 out of 92 publications