The major objectives of the Multipurpose Arthritis Center (MAC) at the University of California, San Francisco (UCSF) are: (1) to conduct basic research in areas related to the etiology and pathogenesis of rheumatic diseases (e.g., basic mechanisms of immunoregulation, genetic control of immune responses, molecular mechanisms of lymphocyte activation, regulation of natural killer cell activity, and the basic cell biology and chemistry of inflammation): (2) to develop and evaluate new methods for the prevention, diagnosis, and treatment of rheumatic disease through clinical research; (3) to conduct research into the health care of patients with rheumatic diseases (e.g., health care costs, disability, and utilization of medical services); (4) to train biomedical scientists, physicians and other health professionals; (5) to conduct education programs for physicians, allied health professionals and patients; and (6) to work with local, state and national organizations for the purpose of developing and applying new knowledge. To meet these objectives, comprehensive programs have been developed at the three major teaching hospitals of the University of California, San Francisco (i.e., Moffitt-Long Hospital, Fort Miley veterans Administration Hospital, San Francisco General Hospital) as well as in the Schools of Medicine and Pharmacy. As components of a MAC, these programs have been organized in such a fashion as to ensure maximum productivity and efficient utilization of resources. The Biomedical Research Program of the MAC at UCSF encompasses ongoing basic research activities (fully funded from other sources) as well as research training activities. Nine Developmental and Feasibility Studies are described in this application. The Community/Health Services Research Program of the UCSF MAC is concerned primarily with health care of patients with rheumatic diseases. Six research projects are proposed as part of this program during the next funding cycle as well as a Core Unit for the maintenance of a panel of patients with rheumatoid arthritis. The projects focus on several emergent social, demographic, and health problems that affect the lives of people (particularly the elderly) with chronic rheumatic diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020684-15
Application #
3108231
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1977-09-15
Project End
1993-12-31
Budget Start
1992-02-05
Budget End
1992-12-31
Support Year
15
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Briggs, F B S; Ramsay, P P; Madden, E et al. (2010) Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. Genes Immun 11:199-208
Yazdany, Jinoos; Yelin, Edward (2010) Health-related quality of life and employment among persons with systemic lupus erythematosus. Rheum Dis Clin North Am 36:15-32, vii
Katz, Patricia P (2006) Childbearing decisions and family size among women with rheumatoid arthritis. Arthritis Rheum 55:217-23
Janssens, A Cecile J W; Steyerberg, Ewout W; Jiang, Yebin et al. (2006) Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile. J Rheumatol 33:2383-9
Yelin, Edward H; Trupin, Laura S; Katz, Patricia P (2005) Impact of managed care on the use of biologic agents for rheumatoid arthritis. Arthritis Rheum 53:423-30
Katz, Patricia P (2005) Use of self-management behaviors to cope with rheumatoid arthritis stressors. Arthritis Rheum 53:939-49
von Scheven, E; Elder, M E (2005) Association between beta2-glycoprotein I gene polymorphisms and pediatric SLE and antiphospholipid antibodies. Lupus 14:440-4
Yang, Nan; Li, Hongzhe; Criswell, Lindsey A et al. (2005) Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine. Hum Genet 118:382-92
Seldin, Michael F; Morii, Takanobu; Collins-Schramm, Heather E et al. (2004) Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping. Genome Res 14:1076-84
Chang, Wenhan; Shoback, Dolores (2004) Extracellular Ca2+-sensing receptors--an overview. Cell Calcium 35:183-96

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