The Biomolecular Core has continued to evolve by providing new services when required, while eliminating other services that became unnecessary. The newest function added during the current year is a Biomolecular Imaging Facility consisting of a Molecular Dynamic Phosphorimager and a Digital Microscopy Facility. The latter is still under development, and will provide MAMDC investigators with state-of-the-art facilities for microscopic image acquisition, analysis, and manipulation. Other functions of the Biomolecular Core include 1) an autoimmune serum blank, cell blank, and clinical databases, 2) a flow cytometry facility, and 3) an inbred mouse colony. Additional functions, formerly par of the Biomolecular Core, are now free-standing and no-longer require support. These include the DNA Sequencing Facility, which was organized under the auspices of the MAMDC and the Program in Molecular Biology, and is now self-supporting. The protein purification and characterization facility also has been eliminated because many of the techniques are well established in individual investigators' laboratories or have been incorporated into the peptide synthesis/analysis facility directed by Dr. David Klapper (see Progress Report). Finally, maintenance of the Center's computing facilities will be taken over by the Numerical Sciences Core (NUSCOR). The purpose of the Biomolecular Core is to provide functions that are required by a large number of investigators but which can not easily be duplicated within each of the individual laboratories. This includes the acquisition, upgrading, and maintenance of costly equipment utilized by several of the individual laboratories involved in biomedical research. Centralizing these facilities results in an economy of scale, allowing access to new technology at a substantially discounted cost to the investigator.

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Corsi, Michela; Alvarez, Carolina; Callahan, Leigh F et al. (2018) Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease. BMC Musculoskelet Disord 19:393
Longobardi, L; Jordan, J M; Shi, X A et al. (2018) Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 26:1257-1261
Raveendran, R; Stiller, J L; Alvarez, C et al. (2018) Population-based prevalence of multiple radiographically-defined hip morphologies: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 26:54-61
Goode, A P; Nelson, A E; Kraus, V B et al. (2017) Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage 25:1672-1679
Barbour, Kamil E; Murphy, Louise B; Helmick, Charles G et al. (2017) Bone Mineral Density and the Risk of Hip and Knee Osteoarthritis: The Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken) 69:1863-1870
Liu, Youfang; Yau, Michelle S; Yerges-Armstrong, Laura M et al. (2017) Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans. J Rheumatol 44:1652-1658
Yau, Michelle S; Yerges-Armstrong, Laura M; Liu, Youfang et al. (2017) Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians. Arthritis Rheumatol 69:343-351
Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang et al. (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun 8:80
Qin, Jin; Barbour, Kamil E; Murphy, Louise B et al. (2017) Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project. Arthritis Rheumatol 69:1204-1212
An, H; Marron, J S; Schwartz, T A et al. (2016) Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage 24:640-6

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