Abstract

of Lyme disease in 1976 and subsequent characterization of its mode of transmission, causative organism and treatment is one of the most important advances in rheumatology in the last 20 years. In theory Lyme disease could be prevented eradicated but in practice it continues to grow as public health problem. We propose a large simple randomized controlled trail of 40,000 subjects to evaluate an innovative educational primary prevention program directed towards a high-risk population, travelers to an island with the highest reported rates of Lyme disease in North America. Ferry boats to Nantucket Island will be randomized to Experimental intervention which is based on contemporary health education principles or to a Control intervention. An economic evaluation will be conducted in the context of the trial.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR036308-15
Application #
6100409
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Koch-Weser, Susan; Rudd, Rima E; Dejong, William (2010) Quantifying word use to study health literacy in doctor-patient communication. J Health Commun 15:590-602
Simard, Julia F; Karlson, Elizabeth W; Costenbader, Karen H et al. (2008) Perinatal factors and adult-onset lupus. Arthritis Rheum 59:1155-61
Costenbader, Karen H; Feskanich, Diane; Mandl, Lisa A et al. (2006) Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women. Am J Med 119:503.e1-9
Karlson, E W; Costenbader, K H; McAlindon, T E et al. (2005) High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women. Lupus 14:832-6
Katz, Jeffrey N; Amick 3rd, Benjamin C; Keller, Robert et al. (2005) Determinants of work absence following surgery for carpal tunnel syndrome. Am J Ind Med 47:120-30
Costenbader, Karen H; Kim, Daniel J; Peerzada, Jehanna et al. (2004) Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis. Arthritis Rheum 50:849-57
Karlson, Elizabeth W; Liang, Matthew H; Eaton, Holley et al. (2004) A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Arthritis Rheum 50:1832-41
Bischoff-Ferrari, H A; Lingard, E A; Losina, E et al. (2004) Psychosocial and geriatric correlates of functional status after total hip replacement. Arthritis Rheum 51:829-35
Iversen, Maura D; Fossel, Anne H; Ayers, Kelly et al. (2004) Predictors of exercise behavior in patients with rheumatoid arthritis 6 months following a visit with their rheumatologist. Phys Ther 84:706-16
Karlson, Elizabeth W; Mandl, Lisa A; Hankinson, Susan E et al. (2004) Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health Study. Arthritis Rheum 50:3458-67

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