This grant proposes to renew the Robert B. Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center (MAC) and supports an Administrative unit, 3 Cores, 3 clinical science grants, and 4 development and feasibility studies. The Cores, Biometry, Morphology and DNA Sequencing, support a variety of biomedical and clinical studies and over 20 investigators. Clinical studies address technology assessment, modification of psychological risk factors to improve outcome, and a primary prevention program and contribute to the basic methodology and understanding of their respective fields. The first study builds on knowledge about the cause and treatment of Lyme Disease and translates this into a primary prevention program aimed at a high-risk population. The trial is the first use of the large simple randomized trial in rheumatic disease. The second study builds on an important finding in SLE, a non-medical modifiable risk factor for disability and disease activity; we propose a controlled evaluation of a psycho-educational intervention to improve self-efficacy in SLE. Our last clinical study examines, in the context of total joint arthroplasty, a fundamental question in the organization of health services: should specialized procedures be regionalized and done only in major centers? The study takes advantage of an emerging technology using administrative data to develop a sample for detailed study of processes and outcomes. The 4 D&F proposals come from some of our most promising junior faculty who have yet to achieve independent NIH funding and examine CD28 independent costimulation of human T-cells in health and disease; pathogenetic mechanisms of a novel T cell in human disease; cellular proteins associated with beta-2 intergrins in lymphocytes; and class II- target transpenics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
3P60AR036308-16S1
Application #
6293144
Study Section
Special Emphasis Panel (ZAR1 (J1))
Program Officer
Freeman, Julia B
Project Start
1985-04-01
Project End
2001-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
16
Fiscal Year
2000
Total Cost
$110,050
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Koch-Weser, Susan; Rudd, Rima E; Dejong, William (2010) Quantifying word use to study health literacy in doctor-patient communication. J Health Commun 15:590-602
Simard, Julia F; Karlson, Elizabeth W; Costenbader, Karen H et al. (2008) Perinatal factors and adult-onset lupus. Arthritis Rheum 59:1155-61
Costenbader, Karen H; Feskanich, Diane; Mandl, Lisa A et al. (2006) Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women. Am J Med 119:503.e1-9
Karlson, E W; Costenbader, K H; McAlindon, T E et al. (2005) High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women. Lupus 14:832-6
Katz, Jeffrey N; Amick 3rd, Benjamin C; Keller, Robert et al. (2005) Determinants of work absence following surgery for carpal tunnel syndrome. Am J Ind Med 47:120-30
Costenbader, Karen H; Kim, Daniel J; Peerzada, Jehanna et al. (2004) Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis. Arthritis Rheum 50:849-57
Karlson, Elizabeth W; Liang, Matthew H; Eaton, Holley et al. (2004) A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Arthritis Rheum 50:1832-41
Bischoff-Ferrari, H A; Lingard, E A; Losina, E et al. (2004) Psychosocial and geriatric correlates of functional status after total hip replacement. Arthritis Rheum 51:829-35
Iversen, Maura D; Fossel, Anne H; Ayers, Kelly et al. (2004) Predictors of exercise behavior in patients with rheumatoid arthritis 6 months following a visit with their rheumatologist. Phys Ther 84:706-16
Karlson, Elizabeth W; Mandl, Lisa A; Hankinson, Susan E et al. (2004) Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health Study. Arthritis Rheum 50:3458-67

Showing the most recent 10 out of 242 publications