Musculoskeletal disorders account for significant dysfunction in the American population. However, estimating the impact of musculoskeletal diseases upon the health status of Americans has been difficult. Current estimates are problematic for at least three reasons. First, estimates from the National Health Interview Survey (NHIS) depend upon self-reports in response to a list of conditions, and there is no verification that those who report arthritis are actually afflicted by these problems. Second, these reports are in response to a one-sixth sample list, meaning that five-sixths of the sampled population do not receive the inquiry about arthritis. Third, reports of dysfunction are not validated against actual observations of dysfunction. A forth problem is that the dysfunction categories captured by the National Health Interview Survey cannot be easily translated into units that are clearly understood by policy makers. The Health Objectives for the Nation, Year 2000, include the requirement for estimating health status using well-years. These measures are scheduled to be included in the National Survey beginning in 1991 or 1992. We propose to evaluate the validity of reports of arthritis and arthritis- related dysfunction for 250 adults by comparing responses to the survey with (1) physical examinations by a rheumatologist and (2) an Internal Consistency Analysis of their responses to QWB questions. In the second phase of the project, a separate sample of 200 adults with arthritis will be given the Quality of Well-being Scale and other NHIS questions. They will then be asked to perform a variety of activities under observation. These observations, and in Internal Consistency Analysis of their responses to the NHIS and Quality of Well-being (QWB) questions, will each be used to estimate the extent to which dysfunction is captured by the survey questions. The third and most important phase of the research will use data from the National Health Interview Survey in order to estimate the number of well-years of life lost due to musculoskeletal disorders. Data for the survey will be analyzed using a variety of multivariate techniques with adjustment for covariates. Reports from the study will be made available to public health policy makers. These studies should provide substantial information about the impact of musculoskeletal diseases in comparison to other diseases that affect the American population.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Malcarne, Vanessa L; Hansdottir, Ingunn; McKinney, Ann et al. (2007) Medical signs and symptoms associated with disability, pain, and psychosocial adjustment in systemic sclerosis. J Rheumatol 34:359-67
Leake, John A D; Albani, Salvatore; Kao, Annie S et al. (2004) Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. Pediatr Infect Dis J 23:756-64
Meyer, Markus; Belke, Darrell D; Trost, Susanne U et al. (2004) A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation. FASEB J 18:1312-4
Groessl, Erik J; Kaplan, Robert M; Cronan, Terry A (2003) Quality of well-being in older people with osteoarthritis. Arthritis Rheum 49:23-8
Kaplan, Robert M (2003) The significance of quality of life in health care. Qual Life Res 12 Suppl 1:3-16
Johnson, Kristen; Goding, James; Van Etten, Deborah et al. (2003) Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res 18:994-1004
La Cava, Antonio; Massa, Margherita; Mendivil, Alberto et al. (2002) Genetic immunization maps T cell (auto)immune responses to self antigens homologous to exogenous proteins. Autoimmunity 35:105-10
Prakken, Berent J; Roord, Sarah; van Kooten, Peter J S et al. (2002) Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope. Arthritis Rheum 46:1937-46
Kaplan, Robert M (2002) Quality of life: an outcomes perspective. Arch Phys Med Rehabil 83:S44-50
Silverman, Gregg J; Goodyear, Carl S (2002) A model B-cell superantigen and the immunobiology of B lymphocytes. Clin Immunol 102:117-34

Showing the most recent 10 out of 94 publications