Abstract

The objective of the proposed Molecular Biology Core unit will be to facilitate the timely utilization of molecular biology techniques by physicians and scientists in the Multipurpose Arthritis Center. Specific functions of the Molecular Biology Core unit will be (1) to establish a shared instrument facility including oligonucleotide synthesis, gene transfection and expression, sequence data collection and analyses; (2) to prepare and provide well characterized cloning vectors; (3) to provide advice and assistance in the basic methodologies of molecular biology for the individual investigators. Finally, the Molecular Biology Core will organize a user group that will meet periodically to assist investigators in the application of new techniques in molecular biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR040770-04
Application #
3747942
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Malcarne, Vanessa L; Hansdottir, Ingunn; McKinney, Ann et al. (2007) Medical signs and symptoms associated with disability, pain, and psychosocial adjustment in systemic sclerosis. J Rheumatol 34:359-67
Leake, John A D; Albani, Salvatore; Kao, Annie S et al. (2004) Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. Pediatr Infect Dis J 23:756-64
Meyer, Markus; Belke, Darrell D; Trost, Susanne U et al. (2004) A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation. FASEB J 18:1312-4
Groessl, Erik J; Kaplan, Robert M; Cronan, Terry A (2003) Quality of well-being in older people with osteoarthritis. Arthritis Rheum 49:23-8
Kaplan, Robert M (2003) The significance of quality of life in health care. Qual Life Res 12 Suppl 1:3-16
Johnson, Kristen; Goding, James; Van Etten, Deborah et al. (2003) Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res 18:994-1004
La Cava, Antonio; Massa, Margherita; Mendivil, Alberto et al. (2002) Genetic immunization maps T cell (auto)immune responses to self antigens homologous to exogenous proteins. Autoimmunity 35:105-10
Prakken, Berent J; Roord, Sarah; van Kooten, Peter J S et al. (2002) Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope. Arthritis Rheum 46:1937-46
Kaplan, Robert M (2002) Quality of life: an outcomes perspective. Arch Phys Med Rehabil 83:S44-50
Silverman, Gregg J; Goodyear, Carl S (2002) A model B-cell superantigen and the immunobiology of B lymphocytes. Clin Immunol 102:117-34

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