The Methodology Core, the heart of the Robert Breck Brigham Multidisciplinary Clinical Research Center, isa centralized resource that provides direction and support for study design, data management, data safetyand monitoring, programming, computing, forms development, statistical analysis, psychometric testing,training and supervision of interviewers, and the education of post-doctoral fellows and other trainees. TheCore serves MCRC investigators, fellows and other trainees in residence within the Section of ClinicalSciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, as well asthe Center's Research Base at Harvard Medical School (HMS) and Harvard School of Public Health (HSPH).The primary objectives of the Core include: 1) To ensure the highest possible methodological rigor in thedesign and implementation of the Center research projects; 2) To provide comprehensive multidisciplinarymethodological support to the Center investigators and the entire Research Base; 3)To carry out specialmethodological studies and activities designed to contribute to MCRC research programs; 4) To facilitate aneducational program for fellows, junior faculty and other trainees through regular consultations with theMethodology Core faculty and monthly didactic seminars led by Senior Center faculty, and 5) To facilitatemultidisciplinary collaboration, brainstorming of grants and projects ideas, as well as monitoring progress ofCenter projects through a weekly research seminar.The Methodology Core is a key resource for ensuring the coupling of innovative ideas with rigorous studydesigns, methods development, appropriate data gathering, compliance with data safety and monitoring andHIPAA regulations, thorough data analysis and clear reporting of findings. The Methodology Core providesthe nucleus for rigorous study of rheumatic and musculoskeletal problems in the MCRC and the entireResearch Base.
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